Clinical Article
β oscillatory activity of subthalamic nucleus is associated with voluntary movement in Parkinson's disease
Qingshan Cui, Ping Zhuang, Yunpeng Wang, Yuqing Zhang, Jianyu Li, Yongsheng Hu, Yongjie Li
Published 2016-05-28
Cite as Chin J Neurosurg, 2016, 32(5): 480-485. DOI: 10.3760/cma.j.issn.1001-2346.2016.05.013
Abstract
ObjectiveTo investigate whether β oscillatory neuron of subthalamic nucleus (STN) is associated with voluntary movement in Parkinson's disease (PD) and to provide the basis for clinical treatment.
MethodsSeventeen patients with PD treated with STN deep brain stimulation (DBS) at the Department of Neurosurgery, Beijing Xuanwu Hospital, Capital Medical University from April 2014 to August 2015 were analyzed retrospectively. The STN cell electrical activities and limb electromyograms on the opposite sides of surgery were collected at the same time using microelectrode and EMG recording techniques during the procedure. The patients were asked to perform 10 s interval of wrist extension movement. The movement was divided into 4 stages according to the movement process: the baseline, before the movement, movement, and after the movement. Single-unit analysis was used to investigate the mean firing rate (MFR) of neurons and the coefficient of variation (CV) of inter-spike intervals. Power spectral analysis was used to investigate the STN oscillatory neuron characteristics. Variance analysis and Bonfferoni test were used to investigate the changes of MFR and CV in different movement stages.
ResultsIn 119 neurons, 38.7% (46/119) were accompanied by β oscillatory activity; their spectrums were 13-30 Hz (21.0±5.1 Hz). In the 46 neurons, 43.5% (20/46) were associated with movement, 26.1% (12/46) showed the desynchronization associated with movement, and 17.4% (8/46) showed the synchronization associated with movement. There were significant differences in the changes of discharge frequency during the movement compared with the baseline (all P<0.05). In addition, the movement-related neurons were mainly distributed in the middle-upper part of STN.
ConclusionsSTN has β oscillatory neurons associated with movement. The changes of discharge frequency may participate in voluntary movement. The neurons associated with movement mainly distribute in dorsal flanking sensorimotor region of STN. It provides the basis for the choice of the best contacts in the DBS treatment of PD.
Key words:
Parkinson's disease; Subthalamic nucleus; β oscillatory neuron; Autonomous wrist extension movement; Microelectrode recording
Contributor Information
Qingshan Cui
Beijing Institute of Functional Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Ping Zhuang
Yunpeng Wang
Yuqing Zhang
Jianyu Li
Yongsheng Hu
Yongjie Li
