Clinical Research and Practice
Treatment of septic shock in children with low dose pituitrin: report of 24 cases
Zi-jiang YANG, Jing-feng LI, Li-min FU, Shang-bing LEI, Jun-hua LIU, Yong WU, Yan-ping HU
Published 2011-11-02
Cite as Chin J Pediatr, 2011, 49(11): 858-861. DOI: 10.3760/cma.j.issn.0578-1310.2011.11.015
Abstract
ObjectiveTo explore the clinical effect of low dose pituitrin in children with septic shock.
MethodsA total of 48 pediatric cases with septic shock, in whom 6 hours, conventional treatment could not reverse shock from January 2008 to December 2010, were selected for this study. The patients were divided into two groups randomly(completely random design)(control group 24, remedial group 24). The conventional treatment included antibiotics/fluid resuscitation/correcting acid-base imbalance, glucocorticoid, organ(heart/lung) support, dopamine 1-15 μg/(kg·min) and norepinephrine 0.5-2 μg/(kg·min) pumped in continuously in the control group. In initial 6 hours the same treatment was given to the remedial group, while low dose pituitrin (0.01-0.03 U/min) was pumped additionally during the rest of time. The therapeutic effect on correcting shock was evaluated in both groups.
ResultsThe total effective rate was 76.2% in the remedial group and 40.0% in the control group; the mortality was 33.3% and 60% respectively. The difference between both groups was significant (P=0.025).
ConclusionLow dose pituitrin could improve the clinical effect significantly in children with septic shock in whom 6 hours conventional treatment failed to correct shock, shorten the total periods of treatment, and decrease mortality.
Key words:
Shock, septic; Pituitary hormones, posterior; Vasopressins; Child
Contributor Information
Zi-jiang YANG
Department of Pediatrics, TaiHe Hospital Affiliated to Hu Bei University of Medicine, Shiyan 442000, China
Jing-feng LI
Li-min FU
Shang-bing LEI
Jun-hua LIU
Yong WU
Yan-ping HU
