Study on Infectious Diseases
Clinical characteristics and antimicrobial resistance of pneumococcal infections from 9 children's hospitals in 2016
Fang Chao, Chen Xuejun, Zhou Mingming, Chen Yinghu, Zhao Ruizhen, Deng Jikui, Jing Chunmei, Xu Hongmei, Yang Jinhong, Chen Yiping, Zhang Hong, Zhang Ting, Cao Sancheng, Deng Huiling, Wang Chuanqing, Wang Aimin, Yu Hui, Wang Shifu, Lin Aiwei, Wang Xing, Cao Qing
Published 2018-08-02
Cite as Chin J Pediatr, 2018, 56(8): 582-586. DOI: 10.3760/cma.j.issn.0578-1310.2018.08.005
Abstract
ObjectiveTo describe the clinical characteristics of pneumococcal infections and drug resistance of Streptococcus pneumoniae isolates from children's hospitals, which would provide reference for preventing and treating pneumococcal diseases.
MethodsThis was a prevalence survey. In this study, the age, specimen type, monthly distribution characteristics, and antimicrobial resistance of Streptococcus pneumoniae isolates from 9 children's hospitals in China were investigated between January 1, 2016 and December 31, 2016. The WHONET 5.6 software was used to analyze the antibiotic susceptibility ofStreptococcus pneumoniae. The comparison of rates was performed by Chi-square test.
ResultsA total of 6 200 isolates of streptococcus pneumoniae were obtained, namely, 95.1% (5 876/6 177) from the respiratory tract specimens, 2.2% (136/6 177) from blood specimens and 0.4% (24/6 177) from cerebrospinal fluid specimens. The isolates were mainly from children older than 1 and younger than 5 years (54.7%, 3 381/6 185) . Most of strains (33.2%, 1 184/3 563) were isolated in November, December and January. Streptococcus pneumoniae isolates were completely sensitive to vancomycin (100.0%, 6 189/6 189) , linezolid (100.0%, 6 030/6 030) , moxifloxacin (100.0%, 3 064/3 064) , highly sensitive to levofloxacin (99.8%, 5 528/5 540), ertapenem (98.8%, 3 024/3 061) and lowly sensitive to erythromycin (1.7%, 102/6 016), clindamycin (3.7%, 116/3 136), and tetracycline (5%, 244/4 877), respectively. According to the parenteral susceptibility breakpoints for non-meningitis isolates, the sensitivity of Streptocococus pneumoniae to penicillin from children's hospital of Chongqing Medical University (49.3%, 892/1 809) was significantly lower than those of other hospitals (χ2=1 268.161, P<0.05) .
ConclusionsStreptococcus pneumoniae is mainly isolated from respiratory tract, from children older than 1 and younger than 5 years and during November to January in tertiary children's hospital of China. TheStreptococcus pneumoniae from children is highly sensitive to vancomycin, linezolid, moxifloxacin, levofloxacin. There are also significant differences in the sensitivity of penicillin for Streptococcus pneumoniae from different hospitals.
Key words:
Pneumococcal infections; Child; Drug susceptibility testing
Contributor Information
Fang Chao
Clinical Laboratory Department, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China
Chen Xuejun
Zhou Mingming
Chen Yinghu
Zhao Ruizhen
Deng Jikui
Jing Chunmei
Xu Hongmei
Yang Jinhong
Chen Yiping
Zhang Hong
Zhang Ting
Cao Sancheng
Deng Huiling
Wang Chuanqing
Wang Aimin
Yu Hui
Wang Shifu
Lin Aiwei
Wang Xing
Cao Qing
