Survey of related factors of maternal venous thromboembolism in nine hospitals of China
Wang Zilian, Geng Huizhen, Zhao Xianlan, Zhu Qiying, Lin Jianhua, Zou Li, Mi Yang, Hu Yali, Fan Shangrong, Chen Xu, Liu Zhe, Yang Huixia
Published 2020-10-25
Cite as Chin J Obstet Gynecol, 2020, 55(10): 667-672. DOI: 10.3760/cma.j.cn112141-20200414-00326
Abstract
ObjectiveTo investigate and analyze disease status and risk factors of venous thromboembolism (VTE) during pregnancy and puerperium in our country.
MethodsClinical datas were collected from 575 patients diagnosed with VTE during pregnancy and puerperium and hospitalized in nine medical institutions in our country from January 1, 2015 to November 30, 2019, and retrospectively analyzed it′s disease status and risk factors.
Results(1) The proportion of VTE in pregnancy and puerperium was 50.6% (291/575) and 49.4% (284/575), respectively. Four patients died, the mortality rate was 0.7% (4/575). The cause of death was pulmonary embolism. (2) The location of VTE during pregnancy and puerperium was mainly in the lower limb vascular (76.2%, 438/575), followed by pulmonary vessels (7.1%, 41/575). (3) In the risk factors of VTE, cesarean section accounted for 32.3% (186/575), maternal advance age accounted for 27.7% (159/575), braking or hospitalization during pregnancy accounted for 13.6% (78/575), other risk factors accounted for more than 5% were previous VTE, obesity, preterm birth, assistant reproductive technology conception and so on, pre-eclampsia and multiple pregnancy accounted for 4.9% (28/575) respectively. In addition, some patients with VTE did not have any of the above risk factors, and the incidence rate was as high as 23.1% (133/575).
ConclusionsThe occurrence of VTE during pregnancy and puerperium is related to multiple risk factors, and could lead to matemal death, It is very necessary to screen VTE risk factors for all pregnant women, to make corresponding prevention and control measures.
Key words:
Venous thromboembolism; Pregnancy; Postpartum period; Risk factors
Contributor Information
Wang Zilian
Department of Obstetrics,the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Geng Huizhen
Department of Obstetrics,the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China
Zhao Xianlan
Department of Obstetrics and Gynecology,the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Zhu Qiying
Department of Obstetrics, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
Lin Jianhua
Department of Obstetrics, Affiliated Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China
Zou Li
Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College of Huazhong University of Science and Technology, Wuhan 430022, China
Mi Yang
Department of Obstetrics, Northwest Women′s and Children′s Hospital, Xi′an 710061, China
Hu Yali
Department of Obstetrics and Gynecology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China
Fan Shangrong
Department of Obstetrics and Gynecology, Peking University Shenzhen Hospital, Shenzhen 518036, China
Chen Xu
Department of Obstetrics, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China
Liu Zhe
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
Yang Huixia
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, China
