Medical Information Research
Effect of levothyroxine treatment on pregnancy outcomes in euthyroid women with thyroid autoantibody positive: a Meta-analysis
Cheng Wenli, Liu Xinru, Zuo Yan, Zheng Wei, Wu Shanshan, Jiang Bi
Published 2021-01-25
Cite as Chin J Obstet Gynecol, 2021, 56(1): 58-63. DOI: 10.3760/cma.j.cn112141-20200312-00215
Abstract
ObjectiveTo conduct a systematic review of the association of levothyroxine treatment with pregnancy outcomes in euthyroid women who are thyroid autoantibody positive.
MethodsMedline, Excerpta Medica (EMBASE), Cochrane Library, China National Knowledge Infrastructure (CNKI), China Biology Medicine (CBM), Wanfang data and VIP database were searched from inception until Jan. 28, 2020. All published randomized controlled trials assessing the association of levothyroxine treatment with pregnancy outcomes in euthyroid women with thyroid autoantibody-positive were included. STATA 11.0 and RevMan 5.3 softwares were used to perform this Meta-analysis.
ResultsA total of 6 studies met the inclusion criteria, with 2 188 women randomized. Meta-analysis showed that there was no significantly association between miscarriage (OR=0.85, 95%CI: 0.65-1.11, P=0.234) and preterm birth (OR=0.79, 95%CI: 0.54-1.16, P=0.224) with levothyroxine treatment.
ConclusionsLevothyroxine therapy could not reduce the risk of miscarriage and preterm birth in euthyroid women with thyroid autoantibody-positive. Therefore, levothyroxine should be used with caution for these pregnant women.
Key words:
Thyroxine; Thyroid gland; Autoantibodies; Pregnancy outcome; Meta-analysis; Randomized controlled trial
Contributor Information
Cheng Wenli
Obstetrics and Gynecology Clinic and Key Laboratory of Birth Defects and Related Women and Children Diseases, West China Second Hospital of Sichuan University, Chengdu 610041, China
Liu Xinru
Obstetrics and Gynecology Clinic and Key Laboratory of Birth Defects and Related Women and Children Diseases, West China Second Hospital of Sichuan University, Chengdu 610041, China
Zuo Yan
Obstetrics and Gynecology Clinic and Key Laboratory of Birth Defects and Related Women and Children Diseases, West China Second Hospital of Sichuan University, Chengdu 610041, China
Zheng Wei
Obstetrics and Gynecology Clinic and Key Laboratory of Birth Defects and Related Women and Children Diseases, West China Second Hospital of Sichuan University, Chengdu 610041, China
Wu Shanshan
Obstetrics and Gynecology Clinic and Key Laboratory of Birth Defects and Related Women and Children Diseases, West China Second Hospital of Sichuan University, Chengdu 610041, China
Jiang Bi
Obstetrics and Gynecology Clinic and Key Laboratory of Birth Defects and Related Women and Children Diseases, West China Second Hospital of Sichuan University, Chengdu 610041, China
