Review
Effect of hormones on keratoconus and its mechanism
Zhao Xiaorui, Yuan Yifei, Zhang Yu, Chen Yueguo
Published 2022-04-11
Cite as Chin J Ophthalmol, 2022, 58(4): 309-314. DOI: 10.3760/cma.j.cn112142-20210425-00189
Abstract
Keratoconus is an ectatic corneal disorder and characterized by central and/or inferior temporal corneal thinning in a cone shape. Studies have shown that its pathogenesis is related to changes in tissue proteins, enzymes, immune functions and specific genes, but the exact pathogenesis has not been clearly clarified yet. Hormones such as sex hormones have been found to be associated with keratoconus. This review aims to summarize and analyze the research progress of the effect of hormones on keratoconus and its mechanism, so as to explore the role of hormones in the early diagnosis of keratoconus and find new targets in the treatment of keratoconus, providing reference for clinical work.
Key words:
Keratoconus; Hormones; Collagen
Contributor Information
Zhao Xiaorui
Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third hospital, Beijing 100191, China
Yuan Yifei
Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third hospital, Beijing 100191, China
Zhang Yu
Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third hospital, Beijing 100191, China
Chen Yueguo
Department of Ophthalmology, Peking University Third Hospital, Beijing Key Laboratory of Restoration of Damaged Ocular Nerve, Peking University Third hospital, Beijing 100191, China
