Objective To compare the coverage errors (CE)of five different shade guides in anterio vital natural teeth of selected people.Methods Anterior vital natural teeth were measured with Crystaleye spectrophotometer,color coordinates of the teeth and five shade guides A (VITA Classical),B (VITA 3D-Master),C (Chromascop),D (Shofu Vintage Halo NCC) and E (Noritake)were analyzed with the supporting software.The CE of the five shade guide systems to natural teeth were evaluated in cervical,body and incisal regions,and difference in CE among shade guides was determined.Results In the cervical region,shade guide A had the maximal CE value (3.09 ±0.97) and shade guide D had the minimal CE value (1.62 ± 0.75).In the body region,CE of shade guide B (1.65 ± 0.64) and shade guide D (1.52 ± 0.74) were lower than those of shade guides A (2.04 ± 0.80),C (2.04 ± 0.90) and E (2.02 ± 0.84) (P ＜ 0.05).In the incisal part,all CE were below 2.00,and again shade guide A had the maximal CE value (1.81 ± 0.86) and shade guide D had the minimal CE value (1.28 ± 0.55).Conclusions Within the limitation of the study,shade guide D had better color coverage of natural teeth in cervical,body and incisal regions.