Original Article
Analysis of birth defect rate trend of cleft lip and palate in Shanghai from 2007 to 2016
Li Li, Huiting Yu, Xudong Wang, Feng Zhou, Fei Wang, Chunfang Wang
Published 2018-05-09
Cite as Chin J Stomatol, 2018, 53(5): 301-306. DOI: 10.3760/cma.j.issn.1002-0098.2018.05.003
Abstract
ObjectiveTo analysis the rate of birth defects of cleft lip and palate among newborns in Shanghai during 2007 and 2016 and describe its change trend, for the purpose of prevention, treatment and nursing of newborns with cleft lip and palate.
MethodsBirth registration information in Shanghai during January 2007 and December 2016 were collected. Rate of birth defects, gender ratio and maternal age of newborns with cleft lip and palate were analyzed. Annual percent change was applied to analyze the trend.
ResultsThe total birth defect rate of children with cleft lip and palate was 937/million in the past 10 years in Shanghai, showing an overall decreasing trend, decreased 28.20% compared to the data of 2007. The total birth defect rate of newborns with cleft lip decreased 40.86%. Overall decline rate of newborns with cleft lip and palate was 54.60%, but birth defect rate of newborns with the isolated cleft palate rised 14.34%. The number of female isolated cleft palate newborns were 1.6 times higher than those of male isolated cleft palate newborns, male newborns with cleft lip were 1.8 times higher than that of the female newborns with cleft lip. Male newborns with cleft lip and palate were 1.5 times as much as the female newborns with cleft lip and palate. Maternal age is mainly 25 to 29 years old, accounting for 42.01% of the total number of mothers, the according birth defect rate was lowest as 853/million. When maternal age is too low or too high, the risk of neonatal cleft lip and palate could increase. Birth defects of cleft lip and palate was up to 130.8/million when maternal age is less than 20, while birth defects of cleft lip and palate was up to 188.2/million when maternal age over 40 years old.
ConclusionsIn recent 10 years, the overall rate of birth defects of cleft lip and palate in Shanghai shows a decreasing trend, with cleft lip and palate declining obviously, but isolate cleft palate has an increasing tendency. Maternal age less than 20 years old or more than 40 years old will increase the risk of birth defects in newborns with cleft lip and palate.
Key words:
Cleft lip; Cleft palate; Birth defect; Trend analysis
Contributor Information
Li Li
Department of Oral and Craniomaxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine &
Shanghai Key Laboratory of Stomatology &
Shanghai Research Institute of Stomatology &
National Clinical Research Center of Stomatology, Shanghai 200011, China
Huiting Yu
Department of Health Information, Shanghai Municipal Central for Disease Control and Prevention, Shanghai 200336, China
Xudong Wang
Department of Oral and Craniomaxillofacial Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine &
Shanghai Key Laboratory of Stomatology &
Shanghai Research Institute of Stomatology &
National Clinical Research Center of Stomatology, Shanghai 200011, China
Feng Zhou
Department of Health Information, Shanghai Municipal Central for Disease Control and Prevention, Shanghai 200336, China
Fei Wang
Department of Shanghai Xuhui Central for Disease Control and Prevention, Shanghai 200237, China
Chunfang Wang
Department of Health Information, Shanghai Municipal Central for Disease Control and Prevention, Shanghai 200336, China
