Oral Histopathology
Clinicopathological observation of 10 cases of salivary secretory carcinoma
Liu Yanyan, Tang Xiaofei, Wang Fengguang, Wang Yumiao, Liu Na, Hu Yehua, Zhao Conghui, Yuan Xiaohong
Published 2022-11-09
Cite as Chin J Stomatol, 2022, 57(11): 1128-1133. DOI: 10.3760/cma.j.cn112144-20220729-00415
Abstract
ObjectiveTo investigate the clinical and pathological features of salivary secretory carcinoma (SSC).
MethodsTen cases of SSC confirmed in the Department of Pathology,Capital Medical University School of Stomatology from January 2014 to December 2021 were retrospectively included, including 5 males and 5 females, with a median age of 46.5 years. The microscopic morphology, immunophenotype, special staining and clinical follow-up of 10 cases of salivary secretory carcinoma were observed. Ten patients were tested with S-100, vimentin, mammaglobin, Dog-1, p63 and Ki-67, 9 cases with cytokeratin (CK) 8/18, 8 with CK7, 6 with calponin, 5 with smooth muscle actin (SMA) and GCDFP15, 4 with CK5/6 and 1 with SOX10. The ETV6-NTRK3 fusion gene was detected by fluorescence in situ hybridization.
ResultsSeven of the 10 SSC were located in the parotid gland and 3 were located in the cheeks. Histomorphology showed solid, papillary-cystic, follicular, microcystic, and macrocystic types. In 7 cases, tumor cells were dominated by single arrangement type, while certain mixed arrangements existed in some areas. The cytoplasm of the tumor cells was rich in eosinophilic, fine granular or vacuolar shapes, and clear cytoplasm was seen in 2 cases. The nuclei were mostly oval-shaped vesicular nuclei, with nucleoli in the center. Immunohistochemistry showed CK7 (8/8) positive, CK8/18 (9/9) positive, S-100 (10/10) positive, vimentin (5/10) positive, (4/10) partially positive and (1/10) less partially positive, mammaglobin (7/10) positive, (1/10) partially positive and (2/10) some individual cells positive, Dog-1 (10/10) negative, CK5/6 (4/4) negative, p63 (7/10) negative and (3/10) partially positive, SMA (5/5) negative, calponin (6/6) negative, and Ki-67 index was 5%-20%. Secretions of 5 cases showed periodic acid-Schiff (PAS) and PAS with diastase (PAS-D) staining positive. All 10 cases showed ETV6-NTRK3 fusion positive. Six cases were successfully followed up for 32-91 months, of which 2 cases recurred after 28 and 74 months and underwent surgical resection again. All cases followed up are alive and disease-free.
ConclusionsThe salivary secretory carcinoma is a rare low-grade malignant tumor. In certain cases, morphology is atypical and mammaglobin is immunohistochemically positive in only individual tumor cells. Therefore, the diagnosis should be supported with morphology, immunohistochemical staining, and molecular feature preferably.
Key words:
Immunohistochemistry; Salivary secretory carcinoma; ETV6-NTRK3; Diagnosis, differential
Contributor Information
Liu Yanyan
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
Tang Xiaofei
Institute of Dental Research, Capital Medical University School of Stomatology, Beijing 100050, China
Wang Fengguang
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
Wang Yumiao
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
Liu Na
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
Hu Yehua
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
Zhao Conghui
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
Yuan Xiaohong
Department of Pathology, Capital Medical University School of Stomatology, Beijing 100050, China
