Epidemiology and Community Control
Association between hematocrit and risk of incident hypertension: a cohort study
Yafei Chen, Chunxia Wang, Zhongshang Yuan, Wenchao Zhang, Yafei Liu, Xiangyi Li, Alimu Dayimu, Yibo Xu, Fuzhong Xue, Chengqi Zhang
Published 2016-11-24
Cite as Chin J Cardiol, 2016, 44(11): 973-978. DOI: 10.3760/cma.j.issn.0253-3758.2016.11.014
Abstract
ObjectiveTo explore the association between hematocrit level and risk of incident hypertension.
MethodSubjects who participated at least two times routine health check-up in Health Management Center of Shandong Province Hospital between January 2005 and January 2010 were eligible for inclusion. After excluding participants with known hypertension and other related diseases, a prospective cohort with 20 606 subjects (female: 8 218, male: 12 388) was established. Cox-proportional hazard model was used to assess the association between hematocrit and the development of hypertension for female and male respectively.
ResultsDuring the 51 352 person-years of follow-up, newly developed hypertension was confirmed in 3 695 cases. For female, the age-adjusted hazard ratios (95%CI) for incident hypertension were 1.00 (reference), 1.06(0.86-1.29), 1.37(1.14-1.65), 1.60(1.34-1.92), respectively (P for trend<0.000 1) through the 3 quartiles of hematocrit levels.After adjusting multiple factors (age, smoking, drinking habit, physical activity, body mass index(BMI), systolic blood pressure, fasting blood glucose, serum creatinine, high-density lipoprotein, gamma-glutamyl transferase, white blood count), the hazard ratios (95%CI) were 1.00(reference), 1.05(0.85-1.29), 1.25(1.03-1.51), and 1.22(1.00-1.48), respectively (P for trend=0.016 9). For male, the hazard ratio (the highest vs. the lowest hematocrit level) after adjusting age or age and life style factors (smoking, drinking habit, physical activity) was 1.23 (1.11-1.37), 1.21(1.09-1.35), respectively. Other analyses of relationship hematocrit with incident hypertension were not statistically significant in male.
ConclusionsHigher hematocrit level is associated with higher risk of incident hypertension, especially in female.
Key words:
Hypertension; Hematocrit
Contributor Information
Yafei Chen
Department of Biostatistics, School of Public Health, Shandong University, Jinan 250012, China
Chunxia Wang
Zhongshang Yuan
Wenchao Zhang
Yafei Liu
Xiangyi Li
Alimu Dayimu
Yibo Xu
Fuzhong Xue
Chengqi Zhang