Neuroradiology
Application of local gyrification index in the early diagnosis of Alzheimer disease
Haimeng Hu, Yingru Lyu, Qiao Li, Bijing Zhou, Qianhua Zhao, Huijin He, Xiaoyuan Feng
Published 2019-05-10
Cite as Chin J Radiol, 2019, 53(5): 345-350. DOI: 10.3760/cma.j.issn.1005-1201.2019.05.004
Abstract
ObjectiveTo evaluate the role of local gyrification index (LGI) in the early diagnosis of Alzheimer disease(AD).
MethodsThirty-five amnestic-type mild cognitive impairment patients (aMCI group), 34 mild AD patients (mild AD group) and 33 healthy volunteers (normal control group) were studied. All patients underwent high resolution MRI examination and mini-mental state examination (MMSE). Using surface-based morphometry, the FreeSurfer was employed to access LGI of vertex over every participant′s whole cortical surface, then we calculated the mean LGI (mLGI) of each subject′s left and right hemisphere separately. Taking age, gender and educational year as covariance, analysis of covariance was used to compare the difference of mLGI of left and right brain among 3 groups, then Bonferroni was done between every two groups. Analysis of covariance was applied to compare the difference of LGI of every participant among 3 groups, and Monte Carlo method was employed to perform multiple comparison corrections. The correlations between the MMSE scores and LGIs of the three groups were analyzed.
ResultsCompared with normal control group(left 3.03±0.12,right 3.02±0.13), the mLGI of hemispheres in mild AD group(left 2.94±0.11,right 2.93±0.10) decreased respectively(P<0.05). The difference of mLGI of hemispheres between aMCI group(left 2.96±0.10, right 2.96±0.09) and normal control group had no statistical significance(P>0.05). The difference of mLGI of hemispheres between aMCI group and mild AD group also had no statistical significance(P>0.05). The aMCI group showed decrease of LGI in some brain regions located at the right temporal lobe, bilateral frontal and parietal lobe compared with the normal control group. While compared with aMCI group, decreased LGIs was presented in some brain regions located at bilateral temporal, occipital, frontal lobe and the right parietal lobe of mild AD group. There was a positive correlation between MMSE scores and LGIs of some brain regions in the bilateral temporal, occipital lobe, the left frontal lobe and the right parietal lobe in the three groups.
ConclusionLGI is conductive in the early diagnosis of AD and can serve as an imaging marker for monitoring disease progresses.
Key words:
Alzheimer disease; Mild cognitive impairment; Magnetic resonance imaging; Local gyrification index
Contributor Information
Haimeng Hu
Shanghai Institute of Medical Imaging, Shanghai 200032, China
Yingru Lyu
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Qiao Li
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Bijing Zhou
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Qianhua Zhao
Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China
Huijin He
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
Xiaoyuan Feng
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040, China
