Geriatric Epidemiology
The relationship between resting heart rate and all-cause mortality among the Chinese oldest-old aged more than 80: a prospective cohort study
Cheng Xin, Li Zhihao, Lyu Yuebin, Chen Peiliang, Li Furong, Zhong Wenfang, Yang Hailian, Zhang Xiru, Shi Xiaoming, Mao Chen
Published 2021-01-06
Cite as Chin J Prev Med, 2021, 55(1): 53-59. DOI: 10.3760/cma.j.cn112150-20200629-00944
Abstract
ObjectiveTo explore the association between resting heart rate(RHR) and all-cause mortality among the Chinese oldest-old aged more than 80.
MethodsUsing a total of seven surveys or follow-ups data (1998, 2000, 2002, 2005, 2008, 2011 and 2014) from the Chinese Longitudinal Healthy Longevity Survey (CLHLS). A total of 17 886 elderly over 80 years old were selected as subjects, their resting heart rate were measured though baseline survey and the survival outcome and death time of the subjects were followed up. The subjects were divided into 6 groups according to their resting heart rate. Cox regression model was used to estimate the effect of resting heart rate on mortality risk. The interaction of age, gender and resting heart rate was also analyzed by likelihood ratio test.
ResultsThe age of subjects M(P25, P75) was 92 (86, 100) years old, including 10 531 females (58.9%) and there were 13 598 participants died, the mortality rate was 195.5 per 1 000 person-years. Multivariate Cox regression analysis showed that compared to the control group (60-69 pbm/min), the hazard ratio of the elderly are 1.06 (95%CI: 1.02, 1.11), 1.09 (95%CI: 1.04, 1.15), 1.23 (95%CI: 1.14, 1.34), 1.25 (95%CI: 1.08, 1.44) in the group of RHR between 70-79, 80-89, 90-99 and ≥100 pbm/min and Pvalues are all less than 0.05. Likelihood ratio test showed that RHR and age had an interaction effect. (P for interaction=0.011).
ConclusionThe risk of all-cause death increased with the increase of resting heart rate and this relationship was stronger between the 80-89 years old people.
Key words:
Aged, 80 and over; Heart rate; Cohort study; All-cause mortality
Contributor Information
Cheng Xin
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Li Zhihao
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Lyu Yuebin
China CDC Key Laboratory of Environment and Populaation Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
Chen Peiliang
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Li Furong
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Zhong Wenfang
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Yang Hailian
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Zhang Xiru
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
Shi Xiaoming
China CDC Key Laboratory of Environment and Populaation Health/National Institute of Environmental Health, Chinese Center for Disease Control and Prevention, Beijing 100021, China
Mao Chen
Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou 510515, China
