Review
Advances on molecular typing methods and evolution of human parainfluenza virus
Jiang Jie, Xu Wenbo, Zhang Yan, Zhu Zhen, Mao Naiying
Published 2022-02-06
Cite as Chin J Prev Med, 2022, 56(2): 203-211. DOI: 10.3760/cma.j.cn112150-20211022-00983
Abstract
Human parainfluenza viruses (HPIVs) is one of the main causes of acute respiratory tract infections in children. HPIVs have been grouped into four serotypes (HPIV1~HPIV4) according to serological and genetic variation. Different serotypes of HPIVs have diverse clinical disease spectrum, epidemic characteristics and disease burden. Based on the nucleotide variation in structural protein genes, HPIVs can be further divided into distinct genotypes and subtypes with diverse temporal and spatial distribution features. The standard molecular typing methods are helpful to clarify the gene evolution and transmission patterns of HPIVs in the process of population transmission. However, the development of molecular epidemiology of HPIVs has been hindered by the lack of a standardized molecular typing method worldwide. Therefore, this study reviewed the viral characteristics, genome structure, existing genotyping methods and evolution of HPIVs, and screened the reference strains for molecular typing, so as to improve the understanding of gene characteristics and molecular typing of HPIVs, and provide an important scientific basis for the monitoring and research of molecular epidemiology of HPIVs in China.
Key words:
Molecular typing; Genotype; Evolution; Human parainfluenza virus
Contributor Information
Jiang Jie
WHO WPRO Regional Reference Laboratory of Measles and Rubella/NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China
Xu Wenbo
WHO WPRO Regional Reference Laboratory of Measles and Rubella/NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China
Zhang Yan
WHO WPRO Regional Reference Laboratory of Measles and Rubella/NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China
Zhu Zhen
WHO WPRO Regional Reference Laboratory of Measles and Rubella/NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China
Mao Naiying
WHO WPRO Regional Reference Laboratory of Measles and Rubella/NHC Key Laboratory of Medical Virology and Viral Diseases/National Measles Laboratory, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing 102206, China
