Review
Constructions and advances of animal models of Pseudomonas aeruginosa infection
Ren Yanying, Liu Ying, Fei Bing, Guo Mengyu, Liu Xinwei, Liu Dongmei, Li Yongwei
Published 2023-06-06
Cite as Chin J Prev Med, 2023, 57(6): 929-934. DOI: 10.3760/cma.j.cn112150-20220826-00843
Abstract
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogenic bacterium with complex pathogenesis and drug resistance mechanisms. It has high morbidity and mortality and can cause acute and chronic infections in immunocompromised individuals, with lung infections, wound infections, and bloodstream infections being the most common. The animal infection model of P. aeruginosa is of great value for in-depth research on the pathogenicity, drug resistance, and therapeutic measures of P. aeruginosa by simulating the pathways of human bacterial infections. This article firstly summarizes the selection, anesthesia, and disposal of experimental animals in the construction of animal models of P. aeruginosa infection, and then reviews the methods of construction, model evaluation, and applications of animal models of P. aeruginosa pulmonary infection, wound infection, and bloodstream infection, in order to provide a reference for scientific research related to P. aeruginosa infectious diseases.
Key words:
Pseudomonas aeruginosa; Models, Animal; Bacterial infections
Contributor Information
Ren Yanying
The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450001, China
Liu Ying
The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450001, China
Fei Bing
The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450001, China
Guo Mengyu
The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450001, China
Liu Xinwei
Medicine Laboratory Center of Henan Province Hospital of Traditional Chinese Medicine, Henan Provincial Key Laboratory of Antibiotics-Resistant Bacterial Infection Prevention &
Therapy with Traditional Chinese Medicine, The Key Laboratory of Pathogenic Microbes &
Antimicrobial Resistance Surveillance of Zhengzhou, Zhengzhou 450002, China
Liu Dongmei
Medicine Laboratory Center of Henan Province Hospital of Traditional Chinese Medicine, Henan Provincial Key Laboratory of Antibiotics-Resistant Bacterial Infection Prevention &
Therapy with Traditional Chinese Medicine, The Key Laboratory of Pathogenic Microbes &
Antimicrobial Resistance Surveillance of Zhengzhou, Zhengzhou 450002, China
Li Yongwei
The Second Clinical Medical College of Henan University of Chinese Medicine, Zhengzhou 450001, China
