Original Article
Concordance between three integrated scores based on prostate biopsy and grade-grouping of radical prostatectomy specimen
Fu Yao, Cai Jie, Chen Yu, Zhou Qiang, Xu Yuemei, Shi Jiong, Fan Xiangshan
Published 2023-04-08
Cite as Chin J Pathol, 2023, 52(4): 353-357. DOI: 10.3760/cma.j.cn112151-20221125-00992
Abstract
ObjectiveTo analyze three different integrated scoring schemes of prostate biopsy and to compare their concordance with the scoring of radical prostatectomy specimens.
MethodsA retrospective analysis of 556 patients with radical prostatectomy performed in Nanjing Drum Tower Hospital, Nanjing, China from 2017 to 2020. In these cases, whole organ sections were performed, the pathological data based on biopsy and radical prostatectomy specimens were summarized, and 3 integrated scores of prostate biopsy were calculated, namely the global score, the highest score and score of the largest volume.
ResultsAmong the 556 patients, 104 cases (18.7%) were classified as WHO/ISUP grade group 1, 227 cases (40.8%) as grade group 2 (3+4=7); 143 cases (25.7%) as grade group 3 (4+3=7); 44 cases (7.9%) as grade group 4 (4+4=8) and 38 cases (6.8%) as grade group 5. Among the three comprehensive scoring methods for prostate cancer biopsy, the consistency of global score was the highest (62.4%). In the correlation analysis, the correlation between the scores of radical specimens and the global scores was highest (R=0.730, P<0.01), while the correlations of the scores based on radical specimens with highest scores and scores of the largest volume based on biopsy were insignificant (R=0.719, P<0.01; R=0.631, P<0.01, respectively). Univariate and multivariate analyses showed tPSA group and the three integrated scores of prostate biopsy were statistically correlated with extraglandular invasion, lymph node metastasis, perineural invasion and biochemical recurrence. Elevated global score was an independent prognostic risk factor for extraglandular invasion and biochemical recurrence in patients; increased serum tPSA was an independent prognostic risk factor for extraglandular invasion; increased hjighest score was an independent risk factor for perineural invasion.
ConclusionsIn this study, among the three different integrated scores, the overall score is most likely corresponded to the radical specimen grade group, but there is difference in various subgroup analyses. Integrated score of prostate biopsy can reflect grade group of radical prostatectomy specimens, thereby providing more clinical information for assisting in optimal patient management and consultation.
Key words:
Prostatic neoplasms; Punctures; Neoplasm grading
Contributor Information
Fu Yao
Department of Pathology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
Cai Jie
Department of Pathology, Nanjing Jiangning Hospital, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210000, China
Chen Yu
Department of Pathology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
Zhou Qiang
Department of Pathology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
Xu Yuemei
Department of Pathology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
Shi Jiong
Department of Pathology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
Fan Xiangshan
Department of Pathology, the Affiliated Drum Tower Hospital, Medical School of Nanjing University, Nanjing 210008, China
