Original Article
An intervention study on the effects of vitamin D3 on cognitive function and blood inflammatory cytokines in patients with Alzheimer's disease
Jia Jingya, Xiong Ying, Chen Chong, Duan Keran, Yang Tong, Wang Hualou, Ma Fei
Published 2021-11-14
Cite as Chin J Geriatr, 2021, 40(11): 1357-1362. DOI: 10.3760/cma.j.issn.0254-9026.2021.11.004
Abstract
ObjectiveTo assess the effects of a 12-month vitamin D3 intervention on cognitive function and blood inflammatory cytokines in subjects with Alzheimer's disease(AD).
MethodsTwo hundred and ten AD patients were randomly divided into the intervention and control groups, with 105 patients in each group.The intervention group received vitamin D3 800 U/day and the control group received a placebo for 12 months.Repeated-measures analysis of variance was used to evaluate the effects of vitamin D and placebo on cognitive performance and blood inflammatory cytokines at baseline, month 6 and month 12.
ResultsDuring the follow-up, serum 25(OH)D3(F=712.086, P<0.001)and 1, 25(OH)2D3(F=372.038, P<0.001)concentrations in the intervention group were significantly higher than those in the control group.Changes in FSIQ, VIQ and PIQ between the groups, between different time points and with interaction between the variables taken into account were statistically significant(allP<0.001). Compared with the control group, interleukin-6(IL-6)(F=341.344, P<0.001)and tumor necrosis factor-α(TNF-α)(F=9.580, P<0.001)levels in the intervention group were significantly decreased, and the ratio of Aβ40 to Aβ42 was increased(F=4.617, P=0.010). There were interaction effects between group and time.Except for intervention effects, the baseline concentration of 25(OH)D3 was positively correlated with scores of FSIQ(β=0.016, P=0.031)and VIQ(β=0.017, P=0.031).
ConclusionsDaily oral vitamin D3 supplementation(800 U/day)for 12 months may improve cognitive function and change inflammatory cytokines in elderly patients with AD.
Key words:
Alzheimer disease; Vitamin D; Inflammatory cytokines; Cognitive function
Contributor Information
Jia Jingya
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China
Xiong Ying
Department of Community, Wangdingdi Hospital, Nankai District, Tianjin 300191, China
Chen Chong
Department of Clinical Laboratory, Tianjin Medical University Cancer Hospital, Tianjin 300060, China
Duan Keran
Department of Biological Sample Resource Sharing Center, Tianjin First Central Hospital, Tianjin 300192, China
Yang Tong
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China
Wang Hualou
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China
Ma Fei
Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin 300070, China
Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin 300070, China
