A flowchart for the diagnosis and differential diagnosis of post-stroke aphasia types in the Chinese language and treatment of post-stroke aphasia
Wang Yinhua, Du Wanliang, Yang Xiaona, Yan Jun, Sun Wei, Bai Jing, Zhou Jiong, Zhou Aihong, Niu Jianping, Li Chuanling, Wang Jian
Abstract
This article aims to comprehensively review the concept, etiology, classification, classical cortical mapping, assessment, a proposed flowchart for the diagnosis and differential diagnosis, treatment, rehabilitation, mechanisms of development and recovery, prognosis, and influencing factors for post-stroke aphasia(PSA)types in the Chinese language.We emphasize the necessity and significance of neuroimaging assessment of the brain and blood vessels and neuropsychological assessment in the diagnosis and differential diagnosis of PSA in Chinese.We also recommend and encourage the use of the dichotomies of internal vs.external and anterior vs.posterior as a starting point, based on the association of anatomical locations of the brain and blood vessels with brain language areas and language disorders.A classification system of PSA in Chinese developed from this approach in the form of a flowchart is well-suited for guiding the clinical treatment of cerebral stroke.Incorporating the "four elements" , the flowchart enables convenient diagnosis, classification and differential diagnosis of PSA in Chinese and facilitates targeted and personalized rehabilitation planning to benefit the patient.This article introduces the use of memantine, piracetam, donepezil and other drugs for PSA treatment, evaluates clinical trials on memantine conducted in China and abroad and its mechanisms of action for the treatment of PSA, and discusses how rehabilitation therapy achieves therapeutic effects.For the treatment of PSA, clinical research and practice using drugs such as memantine, piracetam and donepezil in combination with non-pharmacotherapy and rehabilitation training should be promoted.
Key words:
Post-stroke aphasia; PSA types in Chinese; Dichotomy; Four elements; Diagnosis; Treatment
Contributor Information
Wang Yinhua
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Du Wanliang
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China
Yang Xiaona
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Neurology &
Psychiatry, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China
Yan Jun
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Peking University Sixth Hospital, Peking University Institute of Mental Health, NHC Key Laboratory of Mental Health(Peking University), National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital), Beijing 100191, China
Sun Wei
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Bai Jing
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Zhou Jiong
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Neurology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Zhou Aihong
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing 100053, China
Niu Jianping
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Neurology, The Second Affiliated Hospital of Xiamen Medical College, Xiamen 361021, China
Li Chuanling
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Neurology, Xuzhou Central Hospital, Xuzhou 221009, China
Wang Jian
Department of Neurology, Peking University First Hospital, Beijing 100034, China
Department of Psychology, Guang'anmen Hospital, Beijing 100096, China
