Radiological Biology
Effect of iodine contrast agent on biological responses of CT examination
Qiang Li, Ling Wang, Mingming Yu, Ximing Wang, Feirong Yao, Sheng Li, Chunhong Hu
Published 2017-11-25
Cite as Chin J Radiol Med Prot, 2017, 37(11): 816-820. DOI: 10.3760/cma.j.issn.0254-5098.2017.11.003
Abstract
ObjectiveTo evaluate the effect of iodine contrast agent on the biological responses of CT examination.
MethodsA total of sixty patients with suspected urinary tract disease who underwent computed tomography urography(CTU) examination were randomly divided into control group and experimental group. The control group was treated with routine CTU, where only CT scan was performed on the first day. CTU was added after 3 days. The test group was treated with fractional injection CTU and injected with enhanced scanning agent on the first day. Before and after CT examination, the patients′ peripheral blood was collected and the number of γ-H2AX foci in lymphocytes (mononuclear cells) was measured by immunofluorescence, and the differences of DNA damage in these two groups were observed.
ResultsBefore and after CT examination, the number of γ-H2AX foci was 0.06±0.02 and 1.06±0.27 in the lymphocytes of control group, 0.06±0.03 and 1.42±0.50 in the test group, respectively. Hence, the number of γ-H2AX foci in the test group was increased by 38.14%. Moreover, the change of γ-H2AX foci in these two groups was not influenced by gender, but correlated with ages(between≤50 years old and >50 years old) in control group (t=-4.76, P<0.05) and in test group(t=-8.16, P<0.05).
ConclusionsThe iodine contrast agent can increase DNA damage of CT examination, and therefore the use of iodine contrast agent in CT should be reduced as much as possible in clinical work.
Trial registrationChinese clinical trial registry, ChiCTR-OOC-17013327
Key words:
CT; Iodine contrast agent; Radiation damage; γ-H2AX
Contributor Information
Qiang Li
Ningbo 315040, China
Department of Radiology, Yinzhou Hospital Affiliated to Medical School of Ningbo University
Ling Wang
Department of Radiology, First Hospital Affiliated to Soochow University, Suzhou 215006, China
Mingming Yu
Ningbo 315040, China
Department of Radiology, Yinzhou Hospital Affiliated to Medical School of Ningbo University
Ximing Wang
Department of Radiology, First Hospital Affiliated to Soochow University, Suzhou 215006, China
Feirong Yao
Department of Radiology, First Hospital Affiliated to Soochow University, Suzhou 215006, China
Sheng Li
Ningbo 315040, China
Department of Radiology, Yinzhou Hospital Affiliated to Medical School of Ningbo University
Chunhong Hu
Department of Radiology, First Hospital Affiliated to Soochow University, Suzhou 215006, China
