Radiotherapy
Efficacy of postoperative chemoradiotherapy after radical resection of squamous cell carcinoma of upper thoracic esophagus
Wenbin Shen, Hongmei Gao, Shuchai Zhu, Teng Li, Shuguang Li, Youmei Li, Zhikun Liu, Juan Li, Jingwei Su, Jinrui Xu
Published 2018-05-25
Cite as Chin J Radiol Med Prot, 2018, 38(5): 355-359. DOI: 10.3760/cma.j.issn.0254-5098.2018.05.006
Abstract
ObjectiveTo compare the prognosis of patients with squamous cell carcinoma of the upper thoracic esophagus after radical resection with and without postoperative chemoradiotherapy (POCRT).
MethodsFrom January 2007 to December 2011, 168 patients with upper thoracic esophageal carcinoma who were treated in the Fourth Hospital of Hebei Medical University were retrospectively included in this study. According to the different treatment method, they were divided into simple surgery group (86 cases) and POCRT group (82 cases) respectively. Based on SPSS statistical software, the group data composition, prognostic analysis and multivariate prognostic analysis were performed by χ2 test, Log-rank method and Cox regression model, respectively.
ResultsThe 1, 3, 5 year- survival rate, recurrence rate and distant metastasis rate were 83.9%, 52.4%, 43.5%, 26.5%, 40.8%, 43.4% and 5.3%, 11.4%, 16.9%, respectively. The result of multivariate analysis showed that gender, T stage, N stage and treatment method were independent prognostic factors of overall survival (P=0.020, 0.008, 0.005, 0.000); N staging and treatment method were the independent prognostic factors of local/regional recurrence (P=0.001, 0.003); differentiation and T staging were the independent prognostic factors of distant metastasis (P=0.045, 0.020). The intrathoracic regional recurrence rate of operation only group and POCRT group patients were 44.2% (38/86) and 29.3% (24/82) respectively, where the difference was statistically significant (χ2=7.110, P<0.05). The rate of metastasis were 19.8% (17/86) and 13.4% (11/82) respectively without significant difference (P>0.05).
ConclusionsThe recurrence rate of patients with upper thoracic esophageal squamous cell carcinoma after radical resection was still high. Postoperative chemoradiotherapy can improve the overall survival rate and reduce the recurrence rate, but whether it can reduce the patient′s distant metastasis rate needs further study.
Key words:
Esophageal neoplasms/Esophageal squamous cell carcinoma; Upper thoracic region; Surgical treatment; Postoperative chemoradiotherapy; Prognosis
Contributor Information
Wenbin Shen
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Hongmei Gao
Department of Imaging, The First Hospital of Shijiazhuang, Shijiazhuang 050011, China
Shuchai Zhu
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Teng Li
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Shuguang Li
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Youmei Li
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Zhikun Liu
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Juan Li
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Jingwei Su
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
Jinrui Xu
Department of Radiation Oncology, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China
