Vaccine evaluation-Varicella vaccine
Safety and immunogenicity of co-immunization with varicella vaccine and the triple vaccine against diphtheria, pertussis and tetanus
Xuewen Tang, Xianghu Ma, Xuan Deng, Zhiying Yin, Yanli Ma, Yumin Li, Qingxiao Huang, Dandan Chen, Xiaoqin Liu, Hanqing He, Shuyun Xie, Bin Xu, Haiping Chen
Published 2016-03-31
Cite as Chin J Microbiol Immunol, 2016, 36(3): 202-206. DOI: 10.3760/cma.j.issn.0254-5101.2016.03.008
Abstract
ObjectiveTo evaluate the safety and immunogenicity of co-immunization with varicella vaccine and the triple vaccine against diphtheria, tetanus and pertussis (DPT).
MethodsA total of 734 infants aged about 18 months were recruited in Quzhou and Lishui areas of Zhejiang Province and allocated into three groups including co-immunization group, DPT vaccine immunization group and varicella vaccine immunization group (respectively abbreviated to CI group, DPT group and VV group). Active follow-up observation was conducted regularly after vaccination. Serum-free fluorescent antibody method (FAMA) and enzyme-linked immunosorbent assay were respectively used to detect the levels of IgG against varicella and DPT before and 35 days after vaccination.
ResultsIn general, the majority were well tolerated with the co-immunization of varicella and DPT vaccines. Only swelling and low fever occurred in the three groups with an incidence rate of lower than 3%. No significant differences in the antibody seropositive rate (SR), seroconversion rate (SCR) and geometric mean titer (GMT) of antibodies against varicella were observed between CI and VV groups. The SRs of antibodies against diphtheria, tetanus and pertussis were all greater than 95% in both CI and DPT groups and no significant differences were found between the two groups (P=0.23; P=0.16). The SCR of antibodies against pertussis in CI group was higher than that of DPT group (90.6% vs 41.9%, P<0.001), while the SCR of antibodies against diphtheria in DPT group was higher (89.53% vs 77.36 %, P<0.001). The GMTs of antibodies against diphtheria and tetanus in DPT group were significantly higher than those of the CI group (2.04 vs 1.32, P<0.001; 3.48 vs 2.62, P<0.001).
ConclusionThe vaccination schedule of co-immunization with DPT and varicella vaccines could be recommended to eligible infants.
Key words:
Varicella vaccine; DPT vaccine; Co-immunization; Immunogenicity; Safety
Contributor Information
Xuewen Tang
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Zhejiang University School of Public Health, Hangzhou 310051, China
Xianghu Ma
Shanghai Institute of Biological Products Company Limited, Shanghai 200052, China
Xuan Deng
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Zhiying Yin
Quzhou Center for Disease Control and Prevention, Quzhou 324000, China
Yanli Ma
China National Biotec Group Company Limited, Beijing 100029, China
Yumin Li
Lishui Center for Disease Control and Prevention, Lishui 323000, China
Qingxiao Huang
China National Biotec Group Company Limited, Beijing 100029, China
Dandan Chen
Shanghai Institute of Biological Products Company Limited, Shanghai 200052, China
Xiaoqin Liu
China National Biotec Group Company Limited, Beijing 100029, China
Hanqing He
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Shuyun Xie
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
Bin Xu
China National Biotec Group Company Limited, Beijing 100029, China
Haiping Chen
China National Biotec Group Company Limited, Beijing 100029, China
