Basic Immunology
Distribution of anti-neutrophil cytoplasmic antibody in patients with cardiovascular and cerebrovascular diseases
Guo Yanmin, Cui Jingjing, Liu Xin, Song Wenjie, Liang Ying, Li Weihao, Guo Yaping
Published 2020-10-31
Cite as Chin J Microbiol Immunol, 2020, 40(10): 776-779. DOI: 10.3760/cma.j.cn112309-20191030-00356
Abstract
ObjectiveTo investigate the distribution features of anti-neutrophil cytoplasmic antibody (ANCA) in patients with cardiovascular and cerebrovascular diseases and the clinical characteristics of the patients.
MethodsClinical data of 6 759 patients who were treated in Baoding No.1 Central Hospital for cardiovascular and cerebrovascular diseases during January 2015 to July 2019 were collected and analyzed. ANCA was detected by indirect immunofluorescence (IIF). Antibodies against myeloperoxidase (MPO) and protease 3 (PR3) were detected by enzyme-linked immunosorbent assay (ELISA).
ResultsIIF showed that 558 out of the 6 759 cases tested positive for ANCA with a positive rate of 8.26%. Among them, 382 (68.46%) were positive for perinuclear ANCA (p-ANCA) and 176 (31.54%) were positive for cytoplasmic ANCA (c-ANCA). Anti-MPO and anti-PR3 antibodies were detected in 69 ANCA-positive cases, while the antibodies against other target antigens were detected in 489 cases. The ratio between the two groups was 1∶7.09. The incidence of recurrent respiratory tract infection and pulmonary interstitial lesions in ANCA-positive cases was 69.35% (387/558) and 64.52% (360/558), respectively, which was significantly higher than that in ANCA-negative patients [40.51% (2 512/6 201) and 33.17% (2 057/6 201)].
ConclusionsAnti-MPO and anti-PR3 antibody detection could not replace IIF to detect total ANCA for a high rate of missed diagnosis would be caused. Early detection of ANCA would be of great significance to patients with chronic cardiovascular and cerebrovascular diseases.
Key words:
Anti-neutrophil cytoplasmic antibody; Distribution feature; Cardiovascular and cerebrovascular diseases
Contributor Information
Guo Yanmin
Department of Neurology, Baoding No.1 Central Hospital, Baoding 071000, China
Cui Jingjing
Department of Laboratory Medicine, Baoding No.1 Central Hospital, Baoding 071000, China
Liu Xin
Department of Laboratory Medicine, Baoding No.1 Central Hospital, Baoding 071000, China
Song Wenjie
Department of Laboratory Medicine, Baoding No.1 Central Hospital, Baoding 071000, China
Liang Ying
Department of Laboratory Medicine, Baoding No.1 Central Hospital, Baoding 071000, China
Li Weihao
Department of Special Inspection, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Guo Yaping
Department of Laboratory Medicine, Baoding No.1 Central Hospital, Baoding 071000, China
