Epidemiology Investigation
Retrospective analysis of human papillomavirus infection among women in mainland China
Du Lifang, Ma Zhijing, Jin Yuqin, Zhang Xuefeng, Zhang Hao, Zhang Jing, Li Qiming
Published 2021-12-31
Cite as Chin J Microbiol Immunol, 2021, 41(12): 954-961. DOI: 10.3760/cma.j.cn112309-20211110-00377
Abstract
ObjectiveTo retrospectively analyze the prevalence and genotype distribution of human papillomavirus (HPV) among women in mainland China from the introduction of cervical cancer vaccine to its marketing in China, so as to provide data for comparing HPV prevalence after the application and gradual promotion of HPV vaccine.
MethodsRelated articles published during 2006 to 2016 were retrieved from PubMed, China National Knowledge Infrastructure (CNKI) and Wanfang databases. Data about HPV infection in women receiving physical examination or routine cervical cancer screening and female outpatients were collected and analyzed.
ResultA total of 270 articles were retrieved, in which the sampled women were aged from 13 to 90 years old. Seventy-two articles were about HPV infection in women screened for cervical cancer with a sample size of 580 308 people. The overall results showed that during the 11 years, the five most common high-risk HPV genotypes were HPV52, 16, 58, 68 and 18, and the common low-risk HPV genotypes were HPV81, 43 and 6. The distribution of HPV genotypes varied in different regions, but HPV16, 52 and 58 were always the predominant genotypes. Among the 270 collected articles, 200 analyzed HPV infection in female outpatients with a total of 675 035 cases. The results showed that the top five high-risk HPV genotypes with high prevalence were HPV16, 52, 58, 18 and 33, and the common low-risk types were HPV6, 11 and 81. The analysis of HPV infection rate in seven geographical regions indicated that, although the distribution of the commonly circulating high-risk HPV genotypes varied in different regions, HPV16, 52 and 58 remained the predominant genotypes.
ConclusionsThe present study showed that the prevalence and genotype distribution of HPV infection varied by region, but HPV16, 52 and 58 were always the most common high-risk genotypes and HPV6 was the predominant low-risk genotype in both women screened for cervical cancer and female outpatients. Besides that, the infections of other high-risk genotypes, such as HPV53 and 68, should also be of concern.
Key words:
Human papillomavirus; Genotype; Distribution
Contributor Information
Du Lifang
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
Ma Zhijing
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
Jin Yuqin
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
Zhang Xuefeng
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
Zhang Hao
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
Zhang Jing
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
Li Qiming
The Sixth Laboratory, National Vaccine and Serum Institute, Beijing 101111, China
