Large Cohort Study
Analysis on the heritability of diabetes, based on data from the Chinese adult twins
Gan Fengxia, Gao Wenjing, Lyu Jun, Yu Canqing, Wang Shengfeng, Pang Zengchang, Cong Liming, Dong Zhong, Wu Fan, Wang Hua, Wu Xianping, Jiang Guohong, Wang Xiaojie, Wang Binyou, Chang Zheng, Kuja-Halkola Ralf, Cao Weihua, Li Liming
Published 2019-04-10
Cite as Chin J Epidemiol, 2019, 40(4): 389-393. DOI: 10.3760/cma.j.issn.0254-6450.2019.04.004
Abstract
ObjectiveTo analyze the heritability of diabetes among the Chinese twin adults.
MethodsA total of 10 253 same-sex twin pairs aged 25 years and older, were selected from the Chinese National Twin Registry (CNTR) program. Heritability of diabetes was calculated by using the structural equation model.
ResultsAfter adjusted for age and gender, the overall heritability rates of diabetes were 0.41 (0.15-0.75), 0.83 (0.72-0.91) and 0.34 (0.04-0.73) in the <45 and ≥45 years twin pairs, respectively. After adjusted for age, rates of heritability appeared as 0.37 (0.05-0.78) and 0.88 (0.79-0.94) in men and women, respectively.
ConclusionsDiabetes is affected by both genetic and environmental factors. The genetic effect of diabetes seemed stronger on female than that on male twins but was dying down along with ageing.
Key words:
Diabetes mellitus; Twin study; Heritability
Contributor Information
Gan Fengxia
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Gao Wenjing
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Lyu Jun
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Yu Canqing
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Wang Shengfeng
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Pang Zengchang
Qingdao Center for Disease Control and Prevention, Qingdao 266033, China
Cong Liming
Zhejiang Center for Disease Control and Prevention, Hangzhou 310051, China
Dong Zhong
Beijing Center for Disease Control and Prevention, Beijing 100013, China
Wu Fan
Shanghai Center for Disease Control and Prevention, Shanghai 200336, China
Wang Hua
Jiangsu Center for Disease Control and Prevention, Nanjing 210008, China
Wu Xianping
Sichuan Center for Disease Control and Prevention, Chengdu 610041, China
Jiang Guohong
Tianjin Center for Disease Control and Prevention, Tianjin 300011, China
Wang Xiaojie
Qinghai Center for Disease Control and Prevention, Xining 810007, China
Wang Binyou
Harbin Medical University, Harbin 150001, China
Chang Zheng
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
Kuja-Halkola Ralf
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden
Cao Weihua
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
Li Liming
Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100191, China
