Field Epidemiology
Sero-epidemiological characteristics of hepatitis E in population aged 1-29 years in China, 2014
Wang Fuzhen, Sun Xiaojin, Wang Feng, Liu Jianhua, Zhang Guomin, Zheng Hui, Miao Ning, Zhang Shuang, Zhang Wei, Bi Shengli, Cui Fuqiang, Shen Liping, Liang Xiaofeng
Published 2019-11-10
Cite as Chin J Epidemiol, 2019, 40(11): 1426-1431. DOI: 10.3760/cma.j.issn.0254-6450.2019.11.016
Abstract
ObjectiveTo analyze the epidemiological characteristics of hepatitis E Virus antibody (anti-HEV) in people aged 1-29 years in China in 2014.
MethodsBased on database of the national serologic survey of hepatitis B in people aged 1-29 years in China, in 2014, the sample size was estimated. The serum samples of the people surveyed were randomly selected to detect anti-HEV IgG by using enzyme- linked immunosorbent assay (ELISA). Statistical software SAS 9.1.3 was used to calculate the positive rate of anti-HEV and 95% confidence interval (CI) in different age, gender groups, urban and rural areas and geographic areas by using the Taylor series linear method with sampling weight. The difference was determined by comparing 95%CI.
ResultsA total of 14 106 serum samples were detected from people aged 1-29 years, including 6 996 males (49.60%), 7 013 urban residents (49.72%). The positive rate of anti-HEV was 8.12%(95%CI: 7.19-9.15) in people aged 1-29 years. There was no statistical difference between the men and women, between urban area and rural area. The positive rates of anti-HEV in western area(11.36%, 95%CI: 9.45-13.62) was higher than those in eastern and central areas. The positive rates of anti-HEV were 2.46%, 2.24%, 4.50%, 7.58%, 11.89% and 17.27% in people aged 1-, 5-, 10-, 15-, 20- and 25-29 years, respectively. As the age increased, the positive rate of anti-HEV gradually increased. In different ethnic groups, the positive rate of anti-HEV was higher in Tibetan (18.32%, 95%CI: 12.02-26.90), Zhuang (9.54%, 95%CI: 4.33-19.73) ethnic groups.
ConclusionThe positive rate of anti-HEV declined slightly in China in 2014. It is still necessary to pay close attention to the HEV infection, morbidity of hepatitis E and risk factors in people aged 1-29 years.
Key words:
Hepatitis E; Serology; Epidemiologic characteristic
Contributor Information
Wang Fuzhen
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Sun Xiaojin
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Wang Feng
Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Liu Jianhua
Guangzhou Municipal Center for Disease Control and Prevention, Guangzhou 510440, China
Zhang Guomin
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Zheng Hui
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Miao Ning
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Zhang Shuang
Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Zhang Wei
Department of National Immunization Program, Chinese Center for Disease Control and Prevention, Beijing 100050, China
Bi Shengli
Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Cui Fuqiang
School of Public School, Peking University Health Science Center, Beijing, 100191, China
Shen Liping
Institute of Virology Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Liang Xiaofeng
Chinese Center for Disease Control and Prevention, Beijing 102206, China
