杜江波; 丁叶; 黄磊; 蒋杨倩; 孟庆霞; 宋词; 吕红; 刘晓宇; 徐菠; 林苑; 马红霞; 靳光付; 李红; 凌秀凤; 柯晓燕; 沈洪兵; 胡志斌

doi:10.3760/cma.j.cn112338-20201211-01405

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• 中国国家出生队列 •

中国国家出生队列孤独症谱系障碍亚队列建设概况

中华流行病学杂志, 2021,42(4) : 591-596. DOI: 10.3760/cma.j.cn112338-20201211-01405

摘要

孤独症谱系障碍作为儿童神经发育障碍的代表性疾病，发病率呈现不断上升的趋势，给家庭和社会带来巨大压力和经济负担，探讨其病因及发病机制意义重大。本研究依托中国国家出生队列开展孤独症谱系障碍亚队列建设，并利用该出生队列采用的辅助生殖和自然妊娠同期纳入并随访的平行设计，评价辅助生殖技术对子代神经行为发育的影响，并结合队列采集的多种母体孕期和子代生命早期临床及行为相关信息，综合探究孤独症谱系障碍的发病危险因素。本文将从研究目标、内容、初步进展、优势与不足及进一步展望对该亚队列进行简要介绍，重点展现本研究的总体设计和现阶段进展。

引用本文: 杜江波, 丁叶, 黄磊, 等. 中国国家出生队列孤独症谱系障碍亚队列建设概况 [J] . 中华流行病学杂志, 2021, 42(4) : 591-596. DOI: 10.3760/cma.j.cn112338-20201211-01405.

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孤独症谱系障碍（autism spectrum disorder，ASD），是一类儿童神经发育障碍性疾病，一般在3岁以内起病，主要临床表现为不同程度的社会和（或）交流障碍、狭隘兴趣及重复刻板行为等^［1］。自1943年首次被报道以来^［2］，其发病率呈现逐年上升趋势。WHO 2012年发布的数据显示ASD的全球患病率约为1%^［3］，美国CDC 2020年最新报道数据显示，美国ASD发病率已经达到1.85%^［4］。我国少有大规模流行病学调查数据，据Wang等^［5］2018年发表的汇总44项研究的Meta分析显示，我国ASD患病率约为0.39%，低于世界平均水平^［5］。然而，ASD严重危害儿童身心健康，是我国0~6岁儿童致残的首要原因^［6］；并且ASD会伴随患儿终生，给家庭和社会带来沉重的精神压力和经济负担。

贡献者信息

杜江波

南京医科大学公共卫生学院流行病学系　211166

丁叶

南京医科大学公共卫生学院儿少卫生与妇幼保健学系　211166

黄磊

南京医科大学公共卫生学院儿少卫生与妇幼保健学系　211166

蒋杨倩

南京医科大学公共卫生学院流行病学系　211166

孟庆霞

南京医科大学附属苏州医院生殖与遗传中心，苏州　215002

宋词

南京医科大学公共卫生学院流行病学系　211166

吕红

南京医科大学公共卫生学院流行病学系　211166

刘晓宇

南京医科大学公共卫生学院流行病学系　211166

徐菠

南京医科大学公共卫生学院流行病学系　211166

林苑

南京医科大学公共卫生学院儿少卫生与妇幼保健学系　211166

南京医科大学生殖医学国家重点实验室　全球健康研究中心　211166

马红霞

南京医科大学公共卫生学院流行病学系　211166

南京医科大学生殖医学国家重点实验室　全球健康研究中心　211166

靳光付

南京医科大学公共卫生学院流行病学系　211166

南京医科大学生殖医学国家重点实验室　全球健康研究中心　211166

李红

南京医科大学附属苏州医院生殖与遗传中心，苏州　215002

凌秀凤

南京医科大学附属妇产医院生殖医学中心　210011

柯晓燕

南京医科大学附属南京脑科医院儿童心理卫生研究中心　210029

沈洪兵

南京医科大学公共卫生学院流行病学系　211166

南京医科大学生殖医学国家重点实验室　全球健康研究中心　211166

胡志斌

南京医科大学公共卫生学院流行病学系　211166

南京医科大学生殖医学国家重点实验室　全球健康研究中心　211166

通信作者

胡志斌

南京医科大学公共卫生学院流行病学系　211166

南京医科大学生殖医学国家重点实验室　全球健康研究中心　211166

Email：zhibin_hu@njmu.edu.cn

关键词

孤独症; 队列研究; 辅助生殖; 自然妊娠;

基金项目

国家重点研发计划（2018YFC1004200，2016YFC1000200）

作者声明

引用本文：

杜江波, 丁叶, 黄磊, 等. 中国国家出生队列孤独症谱系障碍亚队列建设概况[J]. 中华流行病学杂志, 2021, 42(4): 591-596. DOI: 10.3760/cma.j.cn112338-20201211-01405.

利益冲突

所有作者均声明不存在利益冲突

历史

出版日期：2021-04-10

收稿日期：2020-12-11

本文编辑

李银鸽

China National Birth Cohort

The Autism Spectrum Disorder Cohort-the sub-cohort of China National Birth Cohort

Du Jiangbo, Ding Ye, Huang Lei, Jiang Yangqian, Meng Qingxia, Song Ci, Lyu Hong, Liu Xiaoyu, Xu Bo, Lin Yuan, Ma Hongxia, Jin Guangfu, Li Hong, Ling Xiufeng, Ke Xiaoyan, Shen Hongbing, Hu Zhibin

Published 2021-04-10

Cite as Chin J Epidemiol, 2021, 42(4): 591-596. DOI: 10.3760/cma.j.cn112338-20201211-01405

Abstract

Autism spectrum disorder (ASD), a representative disease of children's neurodevelopmental disorders, brings huge pressure and financial burden to families and society. It is of great significance to explore its etiology and pathogenesis. Therefore, we established an ASD Cohort based on the existing China National Birth Cohort (CNBC), which applied parallel design to recruit and follow up families who achieved pregnancy after receiving assisted reproductive technologies (ART) and families with spontaneous conception. The main aims of this study are to compare the incidence of ASD among children born after ART with those born under spontaneous pregnancy, and to evaluate the impact of ART on the neurobehavioral development of offspring. Additionally, with a variety of clinical and behavioral related information collected during pregnancy and at early life of offspring, we are able to investigate the risk factors associated with ASD comprehensively. This article briefly introduces the objectives, contents, preliminary progress, strength and limitations, as well as further prospects of the ASD cohort study, mainly focusing on the overall design and current progress.

Key words:

Autism spectrum disorder; Cohort study; Assisted reproductive technology; Spontaneous pregnancy

Contributor Information

Du Jiangbo

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Ding Ye

Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Huang Lei

Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Jiang Yangqian

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Meng Qingxia

Reproductive and Genetic Center, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215002, China

Song Ci

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Lyu Hong

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Liu Xiaoyu

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Xu Bo

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

Lin Yuan

Department of Maternal, Child and Adolescent Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China

State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China

Ma Hongxia

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China

Jin Guangfu

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China

Li Hong

Reproductive and Genetic Center, Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215002, China

Ling Xiufeng

Reproductive Medical Center, Nanjing Medical University Affiliated Maternity and Child Health Hospital, Nanjing 210011, China

Ke Xiaoyan

Child Mental Health Research Center, Brain Hospital Affiliated to Nanjing Medical University, Nanjing 210029, China

Shen Hongbing

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China

Hu Zhibin

Department of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing 211166, China

State Key Laboratory of Reproductive Medicine, Center for Global Health, Nanjing Medical University, Nanjing 211166, China

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