Review
Progress in research of Clostridium perfringens toxin
Zheng Haoran, Bai Lulu, Wang Yuanyuan, Zhong Jiaxin, Lu Jinxing, Deng Huiling, Xie Qun, Wu Yuan
Published 2022-11-10
Cite as Chin J Epidemiol, 2022, 43(11): 1860-1868. DOI: 10.3760/cma.j.cn112338-20220316-00189
Abstract
Clostridium perfringens can produce many kinds of toxins and hydrolase, causing gas gangrene, enteritis and enterotoxemia in both human and animals. It is known that C. perfringens can produce more than 20 toxins and hydrolases. The different toxin types are associated with specific disease types. At present, molecular toxin-typing method by PCR has replaced the traditional serological typing method. In this study, we systematically summarize the types, basic characteristics, pathogenic mechanism and the relationship with disease of C. perfringens toxins to provide evidence for the establishment of rapid detection method, immune antigen screening, antibody preparation and research of related pathogenic mechanism.
Key words:
Diarrhea; Toxin; Clostridium perfringens
Contributor Information
Zheng Haoran
Shaanxi University of Traditional Chinese Medicine, Xi'an 712046, China
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Bai Lulu
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Wang Yuanyuan
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Zhong Jiaxin
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Lu Jinxing
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
Deng Huiling
Xi'an Central Hospital, Xi'an 710003, China
Xie Qun
School of Public Health, Xiangnan University, Chenzhou 423000, China
Wu Yuan
National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China
