Review
Progress in pathogenic spectrum and molecular epidemiology of hand, foot and mouth disease in China in the last decade
Zhang Meng, Chen Xiangpeng, Xie Zhengde
Published 2020-12-30
Cite as Chinese J Exp Clin Virol, 2020, 34(6): 660-664. DOI: 10.3760/cma.j.cn112866-20200407-00112
Abstract
Hand, foot, and mouth disease (HFMD) is an acute infectious disease caused by enteroviruses existing worldwide. Enterovirus 71 (EV-A71), Coxsackievirus A16 (CV-A16) and Coxsackievirus A6 (CV-A6) are the major pathogens of HFMD in the mainland of China. The pathogenic spectrum of HFMD has changed significantly in China. It is related to the epidemic pattern of enterovirus and may also be affected by the application of EV-A71 vaccine. This review focuses mainly on the epidemic patterns, the pathogenic spectrum and the molecular epidemiology of HFMD in the mainland of China.
Key words:
Hand, foot, and mouth disease; Pathogenic spectrum; Molecular epidemiology
Contributor Information
Zhang Meng
Beijing Key Laboratory of Pediatric Respiratory Infectious diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
Chen Xiangpeng
Beijing Key Laboratory of Pediatric Respiratory Infectious diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China
Xie Zhengde
Beijing Key Laboratory of Pediatric Respiratory Infectious diseases, Key Laboratory of Major Diseases in Children, Ministry of Education, National Clinical Research Center for Respiratory Diseases, Research Unit of Critical Infection in Children, Chinese Academy of Medical Sciences, 2019RU016, Laboratory of Infection and Virology, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China