Pyroptosis is a gene-regulated inflammatory cell death that relies on the formation and activation of inflammasome, followed by the cleavage of pro-IL-1β, pro-IL-18, and gasdermin D (GSDMD), which form pores in the cell membrane, Results ing in cell swelling rupture and release of inflammatory factors. In the process of virus infection, cells can recognize the signal of infection and produce pyroptosis, which is beneficial to remove the invading pathogens. However, if the inflammasome is overactivated, it will also cause different degrees of body damage. The virus can also inhibit the pyroptosis through various mechanisms to facilitate its replication. The virus interacts with the host to regulate pyroptosis, which is closely related to the occurrence of viral infectious diseases. The study of pyroptosis caused by virus infection can provide a new idea for the pathogenesis and treatment of viral infectious diseases. This article reviews the molecular mechanism of pyroptosis caused by virus infection.