Review Article
Research advances in subventricular zone irradiation in glioblastoma
Chengang Wang, Yijun Luo, Minghuan Li, Jinming Yu
Published 2017-06-15
Cite as Chin J Radiat Oncol, 2017, 26(6): 702-705. DOI: 10.3760/cma.j.issn.1004-4221.2017.06.022
Abstract
Glioblastoma multiforme (GBM, WHO grade IV) contains some glioma stem cells which have unique self-renewal capacity and multilineage potency. There are numerous neural stem cells in the subventricular zone (SVZ) of adult human brain; it may also act as a storehouse of glioma stem cells that can promote the development and recurrence of a tumor. GBM involving SVZ is prone to early recurrence and intracranial metastasis after resection, so irradiation of the SVZ potentially influences the survival of GBM patients. This review provides a summary of related experimental and clinical studies, and discusses the value of irradiation of the SVZ in GBM patients and the direction of future research.
Key words:
Glioblastoma multiforme; Subventricular zone; Glioma stem cells; Radiotherapy; Prognosis
Contributor Information
Chengang Wang
School of Medicine and Life Sciences, University of Ji’nan, Shandong Academy of Medical Sciences, Ji’nan 250000, China
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Ji’nan 250117, China
Yijun Luo
School of Medicine and Life Sciences, University of Ji’nan, Shandong Academy of Medical Sciences, Ji’nan 250000, China
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Ji’nan 250117, China
Minghuan Li
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Ji’nan 250117, China
Jinming Yu
Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Ji’nan 250117, China
