Preliminary analyses of efficacy and safety of Cyberknife stereotactic body radiotherapy for 26 patients with recurrent cholangiocellular carcinoma after surgery
Zhuang Liu, Minghan Qiu, Zhiqiang Wu, Maobin Meng, Huanhuan Wang, Zhongqiu Wang, Yang Dong, Zhiyong Yuan, Ping Wang
Abstract
ObjectiveTo evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) using Cyberknife in the treatment of patients with recurrent cholangiocellular carcinoma (RCC) after surgery.
MethodsClinical data of 26 patients with recurrent RCC after surgery undergoing Cyberknife SBRT from 2010 to 2015 were retrospectively analyzed. The median recurrence time was 10 months (range 2.0-63.0 months) and the median tumor diameter was 2.8 cm (range 1.2-4.8 cm). The median prescription dose/fraction was 45 Gy/5f (range 40-50 Gy/3-8 f). The tumor progression was evaluated based on enhanced CT or MRI. Overall survival (OS), progression-free survival (PFS) and local control rate (LC) were analyzed by Kaplan-Meier method. Toxicity was assessed using the common terminology criteria for adverse events version 4.0.
ResultsFor the entire cohort, the median OS and PFS were 13.5 months and 6.5 months at a median follow-up of 29.3 months (range 2.1-62.0 months). The 1-and 2-year OS and PFS rates were 52% and 21% as well as 28% and 15%, respectively. Among them, 4 patients (4/26, 15%) were recurrent in situ after SBRT. Three patients experienced grade Ⅲ adverse reactions including 1 case of gastrointestinal reaction, 1 case of liver dysfunction and 1 case of biliary tract infection. Only 1 patient suffered from ≥grade IV gastrointestinal bleeding during the advanced stage.
ConclusionsSBRT using Cyberknife is a safe and effective treatment for patients with recurrent RCC after surgery. The adverse reactions can be tolerated by patients.
Key words:
Cholangiocellular neoplasm/stereotactic body radiotherapy; Cyberknife; Treatment outcome
Contributor Information
Zhuang Liu
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Minghan Qiu
Tianjin People′s Hospital Cancer Center, Third Department of Cancer Therapy, Tianjin 300121, China
Zhiqiang Wu
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Maobin Meng
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Huanhuan Wang
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Zhongqiu Wang
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Yang Dong
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Zhiyong Yuan
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
Ping Wang
Department of Radiation Oncology, Cancer Hospital, Tianjin Medical University, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin′s Clinical Research Center for Cancer, Tianjin 300060, China
