Abdominal Tumor
Prognostic value of combined detection of three indexes in patients with advanced cervical squamous cell carcinoma
Shao Jia, He Aiqin, Zhang Can, Yao Juan
Published 2022-10-15
Cite as Chin J Radiat Oncol, 2022, 31(10): 904-909. DOI: 10.3760/cma.j.cn113030-20220413-00137
Abstract
ObjectiveTo evaluate the prognostic value of combined detection of platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR) and squamous cell carcinoma antigen (SCC) for patients with advanced cervical squamous cell carcinoma undergoing radical radiotherapy.
MethodsClinical data of 127 patients with advanced cervical squamous cell carcinoma who received radical radiotherapy in the Affiliated Tumor Hospital of Nantong University from January 2016 to February 2019 were analyzed retrospectively. The enrolled cases were divided into the survival group and death group according to the survival at the end of 3 years after treatment. The laboratory indexes of peripheral blood were collected before treatment, PLR and NLR were calculated, and the differences of clinical parameters were compared between two groups. The prediction model was established, and the prediction efficiency of PLR, NLR and SCC alone and combined prediction models for 3-year overall survival (OS) in patients with advanced cervical squamous cell carcinoma was compared through the ROC curve. Univariate and multivariate analyses of prognosis were carried out by binary logistic regression model.
ResultsA total of 127 patients with advanced cervical squamous cell carcinoma were included in the study. There were 96 cases in the survival group and 31 cases in the death group. There were significant differences between two groups in FIGO stage, longest diameter of tumor, lymph node metastasis, PLR, NLR and SCC (all P<0.05). The area under ROC curve (AUC) of PLR, NLR and SCC was 0.660, 0.712 and 0.700, respectively. The AUC of PLR+NLR+SCC combined prediction model was increased to 0.784. Logistic multivariate analysis showed that FIGO Ⅲ, FIGO Ⅳ, lymph node metastasis, PLR≥205.555, NLR≥3.060 and SCC≥6.950 ng/ml were the independent risk factors for 3-year OS in patients with advanced cervical squamous cell carcinoma (all P<0.05).
ConclusionsPLR, NLR and SCC have good value in predicting the 3-year OS of patients with advanced cervical squamous cell carcinoma, and the combined prediction model of PLR+NLR+SCC has higher prediction value.
Key words:
Uterine cervical neoplasms, advanced; Platelet-to-lymphocyte ratio; Neutrophil-to-lymphocyte ratio; Squamous cell carcinoma antigen; Prognosis
Contributor Information
Shao Jia
Department of gynecology and oncology, Affiliated Tumor Hospital of Nantong University, Nantong 226361, China
He Aiqin
Department of gynecology and oncology, Affiliated Tumor Hospital of Nantong University, Nantong 226361, China
Zhang Can
Department of gynecology and oncology, Affiliated Tumor Hospital of Nantong University, Nantong 226361, China
Yao Juan
Department of gynecology and oncology, Affiliated Tumor Hospital of Nantong University, Nantong 226361, China
