To explore the relation of clinical characteristics and drug therapeutic effect in patients with obsessive-compulsive disorder (OCD).

Totally 87 patients meeting the DSM-Ⅳ criteria for OCD were recruited. They were assessed with the Y-BOCS and Obsessive-Compulsive Inventory-Revised (OCI-R) to evaluate the degree of obsessive-compulsive symptoms and distress, and Beck Depression Inventor-Ⅱ and Beck Anxiety Inventory to evaluate the degree of depression and anxiety, Childhood Trauma Questionnaire was used to measure the childhood trauma, and the patients were arranged to complete the follow-up of 16 weeks, the reductive rate of Y-BOCS was used to assess efficacy. Pearson correlation and binary logistic stepwise regression were used to analysis the relationship between clinical characteristics and therapeutic effect.

The total effective rate of treatment was 65.3% (47/27). Compared with early-onset OCD patients (n=40), late-onset OCD patients (n=47) showed higher checking scores of OCI-R (3.7±3.3 vs.6.3±3.7; t=-2.50, P<0.05). Higher-trauma OCD patients (n=52) scored higher than lower-trauma OCD patients (n=23) in obsession and Beck Depression Inventor-Ⅱ scores (6.8±3.3 vs.4.5±3.5, t=-2.14,P=0.038; 23.8±12.1 vs. 15.6±5.8, t=-3.08, P=0.003) . The age at onset of OCD was positively correlated with the reductive rate of Y-BOCS (r=0.25, P<0.05) . Logistic regression analysis reported that age of onset entered into the regression model (OR=1.15, P<0.05) .

It suggests that OCD patients with more childhood trauma experience may exhibit more severe obsession, and those with earlier age of onset may exhibit the worse therapeutic effect.

Obsessive-compulsive disorder; Age of onset; Treatment outcome; Childhood trauma; Therapeutic effect