Objective To evaluate the non-motor symptoms (NMS) in Parkinson's disease (PD),and its influence on ability of daily living (ADL) in PD patients.Methods The NMS questionnaires (NMS Quest) from 107 cases of PD were collected to analyze the NMS.Their clinical phenotypes were assessed by Unified Parkinson's Disease Rating Scale (UPDRS),Hoehn-Yahr Scale,and Mini-mental State examination(MMSE).The levodopa equivalent dosage in their treatment was recorded.ADL questionnaires were also collected for evaluation.Multiple regression analysis was used to determine the influence of NMS on ADL.Results The incidence of NMS was 97.2% (104/107) in PD patients and eight of NMS presented in patients in average.Among them the symptoms of nocturia,constipation and reduced memory were the most frequent ones.The motor score of the UPDRS (28.0 ± 16.4) accounted for 48.1% (R~2 = 0.481,P=0.000) of the variance of ADL score.When the NMS score was included in the model,the R~2 increased to 51.1%.Conclusions The NMS are commonly occurred in PD patients,suggesting that PD is probably a severe multisystemic neurodegenerative disorder composed of motor disorders and NMS.The NMS correlates with lower ADL.The NMS in PD should be taken seriously and PD patients should be treated for both motor dysfunction and NMS to increase treatment effectiveness and the quality of their daily livings.