Review
Recent advances in the relationship between cerebral small vessel disease and hemorrhagic transformation after intravenous thrombolysis in acute ischemic stroke
Zhang Shiyu, Tian Li, Li Jinwei, Teng Weiyu
Published 2019-09-08
Cite as Chin J Neurol, 2019, 52(9): 776-780. DOI: 10.3760/cma.j.issn.1006-7876.2019.09.014
Abstract
Cerebral small vessel disease refers to a series of clinical, imaging and pathological syndromes caused by various diseases affecting small arteries, arterioles, capillaries, venules, and venules in the brain, thereby causing ischemia or hemorrhage in brain tissue. At present, intravenous thrombolytic therapy is the first choice for the treatment of acute ischemic stroke, however a large number of studies have shown that the presence of cerebral small vessel disease before acute ischemic stroke increases the risk of intravenous thrombolysis. In this article, the recent research progresses about the relationship between cerebral small vessel disease and hemorrhagic transformation after venous thrombolysis in acute ischemic stroke are reviewed, aiming to provide a new reference for clinical intravenous thrombolytic therapy.
Key words:
Cerebral small vessel disease; Stroke; Intravenous thrombolysis; Hemorrhagic transformation
Contributor Information
Zhang Shiyu
Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
Tian Li
Department of Gerontology, Shengjing Hospital Affiliated to China Medical University, Shenyang 110004, China
Li Jinwei
Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
Teng Weiyu
Department of Neurology, the First Affiliated Hospital of China Medical University, Shenyang 110001, China
