Correlation between the elevation of D-dimer and of deep venous thrombosis progression of the lower extremities after abdominal surgery
Yongshun Gao, Xizhong Yan, Jingjing Huang, Peng Chen, Yunfei Zhang, Xiaojin Fan, Jiangang Sun, Yiming Wang
Published 2017-12-25
Cite as Chin J Gen Surg, 2017, 32(12): 1022-1025. DOI: 10.3760/cma.j.issn.1007-631X.2017.12.012
Abstract
ObjectiveTo investigate the value of D-dimer in predicting the progression of lower extremity deep venous thrombosis (DVT) during perioperative period of gastrointestinal surgery.
MethodsColor Doppler ultrasound was used to dynamically monitor the formation and changes of perioperative deep venous thrombosis (DVT) in 239 patients receiving abdominal surgery in our department from Nov 2014 to Aug 2016.Changes of plasma D-dimer were measured, and clinical data of malignant tumor, infection, age, BMI were collected. The relationship between D-dimer elevation and DVT progression was analyzed.
ResultsLower extremity DVT after surgery developed in 97 patients, and thrombosis progression occurred in 16.6% (16/97). Univariate logistic regression analysis showed that continuous increase of postoperative D-dimer was closely related to the progression of thrombosiss. Multivariate Logistic regression analysis showed that the continuous rise of D-dimer was an independent risk factor for thrombosis. ROC curve analysis showed significantly increased risk of thrombosis progression, when plasma D-dimer polymerization increased >0.87 mg/L on the 3rd day.
ConclusionThe continuous increase of D-dimer >0.87 mg/L predicts DVT progression of lower extremity DVT.
Key words:
Venous thrombosis; Perioperative period; D-dimer; Intermuscular vein thrombosis
Contributor Information
Yongshun Gao
The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450000, China
Xizhong Yan
Jingjing Huang
Peng Chen
Yunfei Zhang
Xiaojin Fan
Jiangang Sun
Yiming Wang
