Sphincter of Oddi dysfunction (SDO) is the obstruction of ampulla of Vater, resulting from abnormality of contraction of sphincter of Oddi, which causes the reflux of bile and pancreatic juice and promotes a series of pathophysiological changes in cholangiopancreatic system. Because of lack of typical clinical symptoms and specific diagnostic methods, the standards of diagnosis and therapy are still unclear. Recently, new changes happened in this field with the development of endoscopy and large-scale clinical trials. This review summarized the latest advances on sphincter of Oddi dysfunction in recent years.

Sphincter of Oddi dysfunction (SOD); Manometry; Sphincterotomy