Original Article
Therapeutic effect analsysis of ultrasound-guided radioactive 125I seed implantation in the treatment of hepatic tumors at dangerous sites
Qi Erpeng, Liu Fangyi, Tan Shuilian, Hu Yanyan, Gao Dengfa, Yu Xiaoling
Published 2019-03-28
Cite as Chin J Hepatobiliary Surg, 2019, 25(3): 161-163. DOI: 10.3760/cma.j.issn.1007-8118.2019.03.001
Abstract
ObjectiveTo study the local efficacy of ultrasound-guided interstitial implantation of radioactive 125I seeds in the treatment of hepatic tumors at dangerous sites.
MethodsA retrospective study was conducted on 39 patients who were admitted into the First Medical Center, PLA General Hospital from November 2011 to January 2018. There were 23 males and 16 females. A three-dimensional planning before 125I seed implantation was performed for all these patients using the treatment planning system (TPS). The implantation was performed under ultrasound guidance. Liver CT scan was performed in all the patients after implantation to evaluate the actual distribution of the seeds in the tumors. Follow-up was performed at 2, 4, 6, 9 and 12 months after implantation, respectively, to evaluate using complete response (CR), partial response (PR), steady disease (SD), progressive disease (PD) and local control rates (LCR).
ResultsImplantation was successfully performed in all the 39 patients. CT scan showed that 5 patients (12.8%) required additional implantation. Follow-up imaging after implantation showed local control of the lesions was good. The rates of CR, PR, SD and LCR were 2.6% (1/39), 28.2% (11/39), 66.7% (26/39) and 97.4% (38/39), respectively. One patient (2.6%, 1/39) showed local progressive disease. The LCR reached 97.4% (38/39) at 12 months of follow-up.
ConclusionUltrasound-guided radioactive 125I seed implantation was efficacious in the treatment of hepatic tumors at dangerous sites.
Key words:
Liver neoplasms; Iodine radioisotopes; Treatment outcome; Ultrasound-guided
Contributor Information
Qi Erpeng
Department of Interventional Ultrasound, the First Medical Center, PLA General Hospital, Beijng 100853, China
Liu Fangyi
Department of Interventional Ultrasound, the First Medical Center, PLA General Hospital, Beijng 100853, China
Tan Shuilian
Department of Interventional Ultrasound, the First Medical Center, PLA General Hospital, Beijng 100853, China
Hu Yanyan
Department of Oncology, the Fourth Medical Center, PLA General Hospital, Beijng 100048, China
Gao Dengfa
Department of Interventional Ultrasound, the First Medical Center, PLA General Hospital, Beijng 100853, China
Yu Xiaoling
Department of Interventional Ultrasound, the First Medical Center, PLA General Hospital, Beijng 100853, China
