Hepatolithiasis is a common biliary tract disease in China with complicated condition, high postoperative residual and high recurrence rate of stones and repeated operations. End-stage biliary disease will be developed at the late stage of hepatolithiasis and seriously affect the quality of life of patients. At present, percutaneous transhepatic choledochoscopic lithotripsy is gradually carried out in clinic, but with many irregularities, which affect the promotion and popularization of the surgery. In order to standardize the implementation of percutaneous transhepatic choledochoscopic lithotomy and provide guidance and reference for minimally invasive lithotomy of hepatolithiasis, this guidance summarized the percutaneous transhepatic choledochoscopic lithotomy in recent years and puts forward recommendations for treatment.