Review
Current status of adjuvant therapy after surgical resection for patients with hepatocellular carcinoma and microvascular invasion
Zhao Yuanquan, Xu Guoqi, Chen Jie
Published 2022-11-28
Cite as Chin J Hepatobiliary Surg, 2022, 28(11): 868-872. DOI: 10.3760/cma.j.cn113884-20220316-00112
Abstract
Hepatectomy and liver transplantation are the most effective radical treatment for patients with hepatocellular carcinoma, but the high recurrence rate after surgery which seriously affects the prognosis of patients cannot be ignored. Microvascular invasion (MVI) is a risk factor for postoperative recurrence and metastasis in patients with hepatocellular carcinoma. There is no consensus or guideline recommendation locally or intermutually on postoperative adjuvant therapy of patients with hepatocellular carcinoma with MVI. Appropriate selection of postoperative adjuvant therapy is worth more in-depth discussion. This article reviews recent and relevant studies on postoperative adjuvant therapy for patients with hepatocellular carcinoma and MVI, including local anti-tumor therapy, systemic chemotherapy, immunotherapy, targeted therapy and combination therapy, with the aim to provide better reference to clinicians in managing these patients with postoperative adjuvant therapy.
Key words:
Carcinoma, hepatocellular; Hepatectomy; Neoadjuvant therapy; Microvascular invasion
Contributor Information
Zhao Yuanquan
Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China
Xu Guoqi
Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China
Chen Jie
Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning 530021, China