Original Article
Comparison of safety of salbutamol and doxofylline treatments with 3 different orders
Zixin Wang, Lijie Liu, Qingling Meng, Wei Chen, Jing Zhang, Hui Zheng, Congying Ji
Published 2016-08-28
Cite as ADRJ, 2016, 18(4): 273-276. DOI: 10.3760/cma.j.issn.1008-5734.2016.04.006
Abstract
ObjectiveTo explore the safety of salbutamol and doxofylline treatments with different orders.
MethodsThe subjects were inpatients who need to be treated with salbutamol and doxofylline in Department of Respiratory and Critical Care Medicine Ward, Beijing Hospital during September 2012 to December 2014. Firstly, the nurses were divided into A, B, and C groups and the admitted patients in accordance with inclusion criteria were entered into the on-duty nurses′ group. The patients in the group A received intravenous injection of doxofylline after salbutamol inhalation, the patients in the group B received salbutamol inhalation and intravenous injection of doxofylline at the same time, and the patients in the group C received salbutamol inhalation after intravenous injection of doxofylline (a total of 1 to 2 treatment cycles, the treatment was stopped if adverse reactions occurred). The adverse reactions in the 3 groups were observed.
ResultsEach group comprised 100 patients. There were 63 males in the group A and average age was (71±13) years; 58 males in the group B and average age was (71±12) years; 64 males in the group C and average age was (73±12) years. The diseases in patients in the 3 groups included chronic obstructive pulmonary disease, pneumonia, lung cancer, lung infection, bronchiectasis, and bronchial asthma, etc. The differences of age, gender distribution, and percentages of different diseases among the three groups were not statistically significant (all P>0.05). Totally 24 cases of adverse reactions appeared in 16 patients in the 3 groups, including 12 cases of palpitations, 10 cases of shortness of breath, and 1 case of finger tremor. The incidence of adverse reactions in the 3 groups were 2% (2/100), 10% (10/100), and 5% (5/100), respectively. The difference between the group A and the group B was statistically significant (P=0.045).
ConclusionsSalbutamol inhalation and intravenous injection of doxofylline with different order had an marked impact on medication safety. The incidence of adverse reactions was the lowest when the patients were given intravenous injection of doxofylline after salbutamol inhalation.
Key words:
Salbutamol; Safety; Doxofylline
Contributor Information
Zixin Wang
Department of Respiratory and Critical Care Medicine, Beijing Hospital, Beijing 100730, China
Lijie Liu
Qingling Meng
Wei Chen
Jing Zhang
Hui Zheng
Congying Ji
