Expert consensus on standardized TORCH laboratory detection and clinical application
Zhu Yuning, Shang Shiqiang, Chen Yinghu, Chen Dapeng, Jia Liting, Qu Wei, Ke Jiangwei, Li Haibo, Li Xiaoqin, Liang Xiuyun, Liu Yanqiu, Ma Lijuan, Mo Liya, Ruan Qiang, Shen Guosong, Wang Yuxin, Xu Hong, Xu Jin, Xu Liangpu, Xu Xiaohong, Yuan Enwu, Zhang Lehai, Zhang Wenli, Zhang Xinwen
Abstract
TORCH, which is considered as a series of pathogens, including the Toxoplasma gondii, Rubella virus, Cytomegalovirus or Herpes simplex virus, often infects the pregnant women to induce the the fetus or newborn infection by transplacental infection or exposure to contaminated genital tract secretions at delivery. Increasing evidence have been confirmed that the infection of TORCH may cause the miscarriage, premature birth, malformed fetus, stillbirth, intrauterine growth retardation, neonatal multiple organ dysfunction and other adverse pregnancy outcomes. For most TORCH-infections cases may lacking the effective treatments during pregnancy, and it is important to achieve the effacing monitoring of TORCH infections before and during pregnancy. The laboratory testing of TORCH has the great significance. However, the consensus opinions still need to improve the the standardization of TORCH testing process and the correct interpretation. Based on the characteristics of the TORCH detection method, this article gives a consensus opinion on the standardized detection and clinical application of TORCH from the laboratory perspective according to the characteristics and types of infection of different pathogens.
Key words:
Cytomegalovirus infections; Herpes simplex; Rubella; Toxoplasmosis; Clinical laboratory techniques; Reference standards
Contributor Information
Zhu Yuning
Department of Clinical Laboratory, Branch of National Clinical Research Center for Obstetrics &
Gynecology, Women′s Hospital, Zhejiang University, Hangzhou 310006, China
Shang Shiqiang
Laboratory Center, National Clinical Research Center for Child Health, National Children′s Regional Medical Center, Children′s Hospital, Zhejiang University, Hangzhou 310052, China
Chen Yinghu
Laboratory Center, National Clinical Research Center for Child Health, National Children′s Regional Medical Center, Children′s Hospital, Zhejiang University, Hangzhou 310052, China
Chen Dapeng
Department of Clinical Laboratory, Children′s Hospital of Chongqing Medical University, Chongqing 400014, China
Jia Liting
Department of Clinical Laboratory, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Qu Wei
Department of Clinical Laboratory, Guiyang Maternal and Child Health Hospital, Guiyang 550003, China
Ke Jiangwei
Department of Clinical Laboratory, the Children′s Hospital of Jiangxi Province, Nanchang 330006, China
Li Haibo
Department of Clinical Laboratory, Nantong Maternal and Child Health Hospital, Nantong 226018, China
Li Xiaoqin
Department of Clinical Laboratory, the Xinjiang Uygur Autonomous Region Maternal and Child Health Care Hospital, Urumqi 830000, China
Liang Xiuyun
Department of Clinical Laboratory, the Second Nanning People′s Hospital, Nanning 530031, China
Liu Yanqiu
Prenatal Diagnosis Center, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang 330006, China
Ma Lijuan
Department of Clinical Laboratory, Capital Institute of Pediatrics Affiliated Children′s Hospital, Beijing 100020, China
Mo Liya
Department of Clinical Laboratory Center, Hunan Provincial Children′s Hospital, Changsha 410007, China
Ruan Qiang
Virus Laboratory, Shengjing Hospital, China Medical University, Shenyang 110004, China
Shen Guosong
Department of Clinical Laboratory, Huzhou Maternity &
Child Health Care Hospital, Huzhou 313000, China
Wang Yuxin
Department of Clinical Laboratory, Dalian Maternal and Child Health Hospital, Dalian 116033, China
Xu Hong
Department of Clinical Laboratory, Shijiazhuang Fourth Hospital, Shijiazhuang 050011, China
Xu Jin
Department of Clinical Medical Laboratory, Children′s Hospital of Fudan University, Shanghai 201102, China
Xu Liangpu
Department of Clinical Laboratory, Fujian Maternity and Child Health Hospital, Fuzhou 350001, China
Xu Xiaohong
Department of Clinical Laboratory, Anhui Maternity and Child Health Hospital, Hefei 230001, China
Yuan Enwu
Department of Clinical Laboratory, the Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Zhang Lehai
Education &
Foreign Affairs Department, Qilu Children′s Hospital of Shandong University, Jinan 250000, China
Zhang Wenli
Department of Medical Laboratory, Children′s Hospital of Urumqi, Urumqi 830002, China
Zhang Xinwen
Department of Obstetrics and Gynecology, Xi′an Fourth Hospital, Xi′an 710004, China
