Review
Research progress in peptides encoded by non-coding RNA
Nie Junjie, Chen Xiaoxiang, Liu Xiangxiang, Sun Huiling, Wang Shukui
Published 2021-10-11
Cite as Chin J Lab Med, 2021, 44(10): 978-982. DOI: 10.3760/cma.j.cn114452-20201217-00908
Abstract
Non-coding RNA (ncRNA) used to be considered as a class of gene transcripts without protein-coding capacity. Whereas emerging evidence has demonstrated that a small fraction of ncRNAs are still capable of producing functional peptides. Such ncRNAs and corresponding peptides are highly conserved and homologous, and can be detected by sequencing or mass spectrometry analysis. In this paper, we searched several databases with the keywords of "non-coding RNA" and "peptide", and briefly reviewed the characteristics of ncRNA that can be translated into functional small peptides, detection methods of peptides, biological functions of peptides and clinical application value of peptides. The results show that these functional peptides are often involved in disease processes, such as regulation of tumor progression, muscle activity and immune disorders. NcRNA-encoded peptides can be used as novel and efficacious disease diagnostic, therapeutic, and prognostic tools, and further develop as anticancer therapeutic targets to provide new ideas for individual precise treatment of tumors.
Key words:
ncRNA; Translation; Coding; Peptides
Contributor Information
Nie Junjie
Clinical Medical Laboratory Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Chen Xiaoxiang
Clinical Medical Laboratory Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Liu Xiangxiang
Clinical Medical Laboratory Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Sun Huiling
Clinical Medical Laboratory Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
Wang Shukui
Clinical Medical Laboratory Center, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China
