Based on the fact that autoantibody plays important roles in the regulation of autoimmune disease, it is valuable to improve the accuracy of autoantibody in laboratory to achieve the better diagnosis, classification, disease assessment, effect observation and prognosis analyses of autoimmune diseases. Although the technology of antoantibody measurement is continuously developing and moving towards quantitation, automation and intelligentization in the past years, the standardization of autoimmune testing has still remained challenged. In this paper, the status and trend for autoimmune testing standardization were systematically summarized, and the approaches or strategies to realize standardization were also discussed.

Autoantibodies; immunoassay; Reference standards