Symposium
The trend and challenge of DNA methylation clinical application in cervical cancer
Liu Yuli, Xie Xiaobing, Chen Fei, Lou Weizhen, Mi Ma, Li Fang
Published 2023-04-19
Cite as Chin J Lab Med, 2023, 46(4): 341-346. DOI: 10.3760/cma.j.cn114452-20221206-00719
Abstract
According to the current cervical cancer screening strategy and the World Health Orgnization cervical cancer diagnosis/screening guidelines, gene methylation will be included in the new guidelines in the future. However, the value of detecting DNA methylation at specific sites in the clinical specimens during the cervical cancer treatment remains to be discussed. This article summarised the role of DNA methylation in the development of cervical cancer and discusses the potential clinical application of methylation detection in the management of high-risk human papillomavirus (hrHPV) positive female patients. It is believed that methylation test can not only be used for the preliminary classification of hrHPV positive female patients, but also for the secondary triage of female patients with slight cytological abnormalities to determine the high risk of cervical intraepithelial neoplasia 3(CIN3) or cancer. It can also be used for the withdrawal test of women in the screening program to support the management of CIN.
Key words:
Uterine cervical neoplasms; Early detection of cancer; Methylation; Cervical intraepithelial neoplasia; Mass screening
Contributor Information
Liu Yuli
Precision Medicine Center, the First Affiliated Hospital of Guangdong Pharmaceutical University, Guangzhou 510000, China
Xie Xiaobing
Medical Laboratory and Pathology Center, the First Affiliated Hospital of Hunan University of Traditional Chinese Medicine, Changsha 410007, China
Chen Fei
National Clinical Research Center for Obstetric &
Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
Peking Union Medical College, Beijing 100730, China
Lou Weizhen
National Clinical Research Center for Obstetric &
Gynecologic Diseases, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences &
Peking Union Medical College, Beijing 100730, China
Mi Ma
Department of Gynecology, People′s Hospital of Tibet Autonomous Region, Lhasa 850000, China
Li Fang
Department of Gynecology, People′s Hospital of Tibet Autonomous Region, Lhasa 850000, China
