Guideline and Consensu
Chinese expert consensus on detection technologies for early-stage gastric cancer screening
Committee of Laboratory Medicine of Chinese Association of Integrative Medicine
Published 2023-04-19
Cite as Chin J Lab Med, 2023, 46(4): 347-359. DOI: 10.3760/cma.j.cn114452-20220728-00440
Abstract
Gastric cancer (GC) is one of the most prevalent malignant tumors in China. Since gastric cancer exhibits less severe symptoms and signs in the early stages, about 90% of patients are already in the intermediate-stage or advanced stage at the time of first diagnosis, which is related to the lower five-year survival rate of these patients. Endoscopy and biopsy are widely considered as the "gold standard" for detecting GC, it is challenging to use them as large-scale screening methods due to the large population and limited distribution of resources and services in China. In contrast, the detection technologies for early cancer diagnosis exhibit great potential in screening of early-stage GC due to non-invasiveness, convenience, and high sensitivity. This consensus document summarizes recent detection techniques associated with the early diagnosis of GC, including breath test, serological and immunological test, and molecular diagnostics technologies. We also discussed the clinical application and characteristics of early gastric cancer-related markers, such as Helicobacter pylori, PGI/II, gastrin-17, tumor markers, and DNA methylation markers in diagnosing early GC. This consensus aims to provide patients, clinicians, and health administrative departments with standardized screening strategies and guidance on detection technologies with significant clinical values.
Key words:
Stomach neoplasms; Clinical laboratory techniques; Early diagnosis; Screening
Contributor Information
Committee of Laboratory Medicine of Chinese Association of Integrative Medicine