Autogenous fat has been widely used in the field of plastic and aesthetic surgery due to its rich source, easy harvesting, no immune rejection, reusable, low cost and relatively simple operation.Fat tissue is rich in fat stem cells and cytokines, which can stimulate tissue regeneration. However, due to the large diameter of fat particles obtained by traditional method, it is difficult to apply them to the deep dermis and subcutaneous layer.In 2013, the concept of nanofat was first proposed, in which autogenous granular fat extracted by negative pressure was mechanically emulsified and filtered.This paper reviews the recent literature on the preparation and naming of nanofat, as well as the basic research and clinical applications.