Pathological repair after tissue injury is caused by massive deposition of collagenous extracellular matrix components, which can lead to pathological scar due to hyperplasia of dermal tissue, including hypertrophic scar with localized growth and keloid with growth beyond the wound edge. Keloids is difficult to treat and easy to relapse, single operation, non-operation and other traditional treatment method could not achieve good therapeutic effect. The pathogenesis of keloid is still unclear, involving genes, cytokines, inflammatory mediators, immune responses, environmental factors and many other factors. At present, the academic community generally believes that keloid has a certain genetic tendency, which is caused by the joint effect from multiple genes and factors. In this paper, the author summarized that their team has used lentivirus gene transfection, whole gene resequencing technology, GO annotation and signal pathway analysis to screen keloid genes in Han Chinese families since 2009, and preliminarized the etiology and gene therapy targets of keloid, then established an animal model of hypertrophic scar in nude mice. They explored the effect and mechanism research for the treatment of hyperplastic scar with Adipose derived stem cells(ADSCs) in chyle fat, combined with keloid susceptible gene related research and the main experience of the biological treatment by ADSCs, on the basis of the traditional sense of scar occurred and the treatment, proposed the new way of thinking in scar susceptible and biological prevention in the following summary.