Review
Research progress in the pathogenesis of keloids
Su Zhiguo, Fan Jincai, Liu Liqiang, Jiao Hu, Chen Hongbo, Chen Yihua
Published 2022-02-25
Cite as Chin J Plast Surg, 2022, 38(2): 228-231. DOI: 10.3760/cma.j.cn114453-20200217-00048
Abstract
The etiology and pathogenesis of keloid are still not clear. It is believed that the formation of keloid is due to the joint action of many factors, during which process the external factor of fibroblast play an important role. Reprogramming of glucose metabolism in keloid fibroblasts is a new research direction. TGF-β1 and its related TGF-β1/Smad signalling pathway are considered to be the most closely related to the formation of keloid. This article reviews the research progress on extracellular factors, glucose metabolism and signaling pathways of keloids.
Key words:
Keloid; Pathogenesis; Inflammation; Glucose metabolism; Signaling pathway
Contributor Information
Su Zhiguo
Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
Fan Jincai
Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
Liu Liqiang
Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
Jiao Hu
Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
Chen Hongbo
Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
Chen Yihua
Ninth Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100144, China
