Keloid, a malignant skin fiber proliferative disease. Pains, itching, non-aesthetics and disorders caused by scar contracture compromise the life of patients. The pathogenesis is not yet fully elucidated. At present, there are many treatment options for keloid, but there is no therapy that can achieve satisfactory result. In this study, literature review for Chinese and foreign researches was conducted to conclude the progress in experimental research progress and clinical treatment of keloid. This provides a novel study review.