Clinical Medicine
Clinical study of the therapeutic efficacy from different dosages of pralidoxime chloride used in patients with acute organophosphorus pesticide poisoning
Lei Wang, Zehai Tang, Kui Chen, Fei Lyv, Hong Fan, Peng Sun, Jiyuan Han
Published 2017-08-10
Cite as Chin J Emerg Med, 2017, 26(8): 924-928. DOI: 10.3760/cma.j.issn.1671-0282.2017.08.019
Abstract
ObjectiveTo investigate the effect of different doses of pralidoxime chloride on clinical outcome including recovery rate and mortality in patients with acute organophosphorus pesticide poisoning.
MethodsAccording to the total amount of pralidoxime chloride administered over the first 24 hours or entire duration of hospitalization, a cohort of 163 organophosphorus pesticide poisoning patients, admitted from February 2004 to December 2014 were assigned to different groups followed by a retrospective analysis. Comparisons of recovery rate, mortality rate, mean length of hospital stay, and duration of mechanical ventilation were made among groups. SPSS 18.0 was used to analyze categorical variables between the data of groups with χ2 test/Fisher exact probability method and numerical variables with t test or One-way ANOVA, and statistical significance was set as P<0.05.
ResultsAccording to the amount of pralidoxime chloride given over the first 24 hours, the recovery rate and the mortality rate were significantly improved in the experimental group (pralidoxime chloride>2 g) than in the control group (pralidoxime chloride<2 g) (P=0.04). There was no significant difference in mean length of hospital stay between the experimental group and the control group (P=0.171), and there were statistically significant differences in recovery rate and mortality rate among the four dose-response subgroups (total dosage administered in 24 hours in group A <1 g, in group B <2 g, in group C <4 g and in group D >4 g) (P=0.034). Based on the total amount of pralidoxime chloride prescribed in the entire duration of hospital stay, the recovery rate and mortality rate were significantly better in the experimental group than those in control group (P=0.002), and among the three dose-response subgroups, the significant difference in recovery rate and mortality rate were also observed (P=0.006).
ConclusionsIncreased amounts of pralidoxime chloride prescribed in the first 24 hours and in the whole hospitalized period can improve the recovery rate and reduce the mortality rate in organophosphorus pesticide poisoning patients.
Key words:
Acute organophosphorus pesticide poisoning; Insecticide; Pesticide poisoning; Cholinesterase agents; Oxime; Pralidoxime chloride; Pralidoxime iodide; Antidote; Dosage
Contributor Information
Lei Wang
Department of Emergency Medicre, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
Zehai Tang
Kui Chen
Fei Lyv
Hong Fan
Peng Sun
Jiyuan Han
